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Nature 399, 105-108 (13 May 1999) | doi:10.1038/20079

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Cell signalling:  Calmodulin at the channel gate

Michael D. Ehlers1 & George J. Augustine1

Of all the channels that conduct ions in response to voltage changes across cell membranes, those that carry calcium merit special attention. The Ca2+ that enters through these channels acts as a messenger for a host of intracellular signalling events, including feedback processes that regulate activity of the channel itself.

  1. Michael D. Ehlers and George J. Augustine are in the Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, North Carolina 27710, USA.
    e-mails: Email: ehlers@neuro.duke.edu georgea@neuro.duke.edu