FIGURE 1. Misexpression of Tbx5 and Tbx4 converts the wing/leg identity of limb buds.

From the following article:

Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds

Jun K. Takeuchi, Kazuko Koshiba-Takeuchi, Ken Matsumoto, Astrid Vogel-Höpker, Mayumi Naitoh-Matsuo, Keiko Ogura, Naoki Takahashi, Kunio Yasuda and Toshihiko Ogura

Nature 398, 810-814(29 April 1999)



ac, Normal expression patterns of Tbx5 (a), Tbx4 (b) and Pitx1 (c) genes at stage 23. df, Tbx5 misexpressed leg. Leg ectoderm is covered by feathers (d, red arrowhead). Fibula is elongated and makes a joint at its distal end like a normal ulna (f). e, Partial scale-to-feather conversion in the area indicated by broken lines. g, Skeletal pattern of the normal leg. hj, Tbx4 misexpressed wings. The wing was elongated and four separated digits were formed with claws (red arrowheads, i). Four digits and a thin ulna are observed (red arrowheads, j). r, radius; u, ulna; fe, femur; fi, fibula; t, tibia; I–IV, digits.