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Nature 398, 723-728 (22 April 1999) | doi:10.1038/19554;
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Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
We have generated and analysed null mutations in the mouse genes encoding three structurally related receptors with tyrosine kinase activity: Tyro 3, Axl, and Mer. Mice lacking any single receptor, or any combination of two receptors, are viable and fertile, but male animals that lack all three receptors produce no mature sperm, owing to the progressive death of differentiating germ cells.
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