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Nature 398, 200-201 (18 March 1999) | doi:10.1038/18327

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Transcriptional regulation:  Modification by nuclear export?

Patrick G. Hogan1 & Anjana Rao1

The length of time that transcription factors remain active in the nucleus is critical for regulating gene transcription. Transcription factors — or enzymes that modulate their activity — are transported into or out of the nucleus by proteins that recognize nuclear-localization signals (NLS) and nuclear-export signals (NES), respectively1,2.

  1. Patrick G. Hogan and Anjana Rao are at the Center for Blood Research and Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
    e-mails: Email: hogan@cbr.med.harvard.edu Email: arao@cbr.med.harvard.edu