Table of contents


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Opinion

Dangers of Euro-relevance p1

The European Commission has clarified aspects of its next Framework programme of research. An insistence on quick delivery of socio-economic benefits threatens the programme's success.

doi:10.1038/17842


Where next on misconduct? p1

Tackling scientific fraud has generated its own problems, while others remain unaddressed.

doi:10.1038/17844


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News

Anomalies in French blood inquiry over 'misleading' report p3

Declan Butler

doi:10.1038/17846


British drive for more women in science p4

Natasha Loder

doi:10.1038/17849


Indian budget boost targets innovation, vaccines and genetics p4

K. S. Jayaraman

doi:10.1038/17852


US aid to Russian weapons labs defended p5

Colin Macilwain

doi:10.1038/17855


Japanese institutes face greater autonomy p5

Asako Saegusa

doi:10.1038/17858


Collapse of talks on safety of GMO trade p6

Ehsan Masood

doi:10.1038/17860


NASA plans two-stage Hubble repair to keep the data flowing p6

Tony Reichhardt

doi:10.1038/17863


Germany aims for competitive equality p7

Alison Abbott

doi:10.1038/17865


Head of German particle physics lab dies p7

Alison Abbott

doi:10.1038/17868


South Africa stands firm on AIDS drug ... p8

Michael Cherry

doi:10.1038/17870


...while forecasting benefits from NASA funds p8

Michael Cherry

doi:10.1038/17873


Canadians protest over rare species bill p9

David Spurgeon

doi:10.1038/17875


Varmus wish list guides senators in fight for biomedical funding p9

Meredith Wadman

doi:10.1038/17878


News in Brief p10

doi:10.1038/17880


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Briefings

Science comes to terms with the lessons of fraud p13

doi:10.1038/17883


Japanese scandals raise public distrust p14

doi:10.1038/17890


Editors debate whether to blow the whistle on suspect papers p15

doi:10.1038/17892


US stalls on new definitions of misconduct p16

doi:10.1038/17894


Guidelines on the web p17

doi:10.1038/17896


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Correspondence

Papers vanish in mis-citation black hole p19

Janne S. Kotiaho

doi:10.1038/17898


Engineering a longer life p19

Nigel L. Firth

doi:10.1038/17901


Managing SOHO p19

Joseph B. Gurman

doi:10.1038/17903


Controversy over the cloning of mice p19

Karl Illmensee

doi:10.1038/17905


Forging links in an electronic paper chain p20

Mark Gerstein

doi:10.1038/17907


The editor as an endangered species p20

Gene L. Wells

doi:10.1038/17909


Space-grown crystals may prove their worth p20

Naomi E. Chayen and John R. Helliwell

doi:10.1038/17911


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News and Views

From rifting to drifting p21

Fred F. Pollitz

doi:10.1038/17913


Protein recognition:  An SH2 domain in disguise p22

John Kuriyan and James E. Darnell, Jr

doi:10.1038/17916


100 and 50 years ago p23

doi:10.1038/17920


Cosmology:  Evolution of the cosmological constant p25

P. J. E. Peebles

doi:10.1038/17922


Signal transduction:  A taste of things to come p25

Alison Mitchell

doi:10.1038/17924


Immunology:  Accessory to murder p26

Ton N. M. Schumacher

doi:10.1038/17927


Oceanography:  The mystery of the sapropels p27

Connie Sancetta

doi:10.1038/17930


Cell signalling:  DREAM on without calcium p29

Gail Mandel and Richard H. Goodman

doi:10.1038/17933


Daedalus:  Bugging the brain p30

David Jones

doi:10.1038/17936


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Scientific Correspondence

Designing tie knots by random walks p31

Thomas M. Fink and Yong Mao

doi:10.1038/17938


Pasture damage by an Amazonian earthworm p32

Armand Chauvel, Michel Grimaldi, Eleusa Barros, Eric Blanchart, Thierry Desjardins, Max Sarrazin and Patrick Lavelle

doi:10.1038/17946


Using hair to screen for breast cancer p33

Veronica James, John Kearsley, Tom Irving, Yoshiyuki Amemiya and David Cookson

doi:10.1038/17949


Change-blindness as a result of 'mudsplashes' p34

J. Kevin O'Regan, Ronald A. Rensink and James J. Clark

doi:10.1038/17953


Top

Book Reviews

From Daedalus to NASA p35

G. Siegfried Kutter

doi:10.1038/17956


Counting on statistics p36

Jonathan Rosenhead

doi:10.1038/17959


Decision-making for our ecological future p37

Marc Mangel

doi:10.1038/17962


Super news p38

A. J. Leggett

doi:10.1038/17964


Science in culture p38

Martin Kemp

doi:10.1038/17966


Top

Article

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport p39

Ingrid R. Vetter, Christine Nowak, Takeharu Nishimoto, Jürgen Kuhlmann and Alfred Wittinghofer

doi:10.1038/17969


Top

Letters to Nature

Superconductivity mediated by spin fluctuations in the heavy-fermion compound UPd2 Al3 p47

M. Jourdan, M. Huth and H. Adrian

doi:10.1038/17977


Coherent displacement of atoms during ion irradiation p49

K. Nordlund, J. Keinonen, M. Ghaly and R. S. Averback

doi:10.1038/17983


Two-photon polymerization initiators for three-dimensional optical data storage and microfabrication p51

Brian H. Cumpston, Sundaravel P. Ananthavel, Stephen Barlow, Daniel L. Dyer, Jeffrey E. Ehrlich, Lael L. Erskine, Ahmed A. Heikal, Stephen M. Kuebler, I.-Y. Sandy Lee, Dianne McCord-Maughon, Jinqui Qin, Harald Röckel, Mariacristina Rumi, Xiang-Li Wu, Seth R. Marder and Joseph W. Perry

doi:10.1038/17989


Photocontrolled nanophase segregation in a liquid-crystal solvent p54

Yves Lansac, Matthew A. Glaser, Noel A. Clark and Oleg D. Lavrentovich

doi:10.1038/17995


The role of mat-forming diatoms in the formation of Mediterranean sapropels p57

Alan E. S. Kemp, Richard B. Pearce, Itaru Koizumi, Jennifer Pike and S. Jae Rance

doi:10.1038/18001


Low-temperature thermal generation of hydrocarbon gases in shallow shales p61

Devon Rowe and Atis Muehlenbachs

doi:10.1038/18007


Evidence for motion between Nubia and Somalia along the Southwest Indian ridge p64

Dezhi Chu and Richard G. Gordon

doi:10.1038/18014

See also: News and Views by Pollitz


Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation p67

Paul A. Garris, Michaux Kilpatrick, Melissa A. Bunin, Darren Michael, Q. David Walker and R. Mark Wightman

doi:10.1038/18019


Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose p70

Andreas H. Guse, Cristina P. da Silva, Ingeborg Berg, Alla L. Skapenko, Karin Weber, Petra Heyer, Martin Hohenegger, Gloria A. Ashamu, Hendrik Schulze-Koops, Barry V. L. Potter and Georg W. Mayr

doi:10.1038/18024


Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells p74

Jose Manuel Cancela, Grant C. Churchill and Antony Galione

doi:10.1038/18032


Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen p77

Luis J. Sigal, Shane Crotty, Raul Andino and Kenneth L. Rock

doi:10.1038/18038

See also: News and Views by Schumacher


DREAM is a Ca2+-regulated transcriptional repressor p80

Angel M. Carrión, Wolfgang A. Link, Fran Ledo, Britt Mellström and Jose R. Naranjo

doi:10.1038/18044

See also: News and Views by Mandel & Goodman


Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase p84

Wuyi Meng, Sansana Sawasdikosol, Steven J. Burakoff and Michael J. Eck

doi:10.1038/18050

See also: News and Views by Kuriyan & Darnell


Erratum:  Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase p90

Heather P. Harding, Yuhong Zhang and David Ron

doi:10.1038/18057


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