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Nature 396, 623-624 (17 December 1998) | doi:10.1038/25234

Structural biology:  The ABC of a versatile engine

Michael J. Welsh1, Andrew D. Robertson1 & Lynda S. Ostedgaard1

Early in evolution an engine called a nucleotide-binding domain (NBD) was created. As evolution progressed, this engine proved quite adaptable — it now powers an amazing variety of machines.