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Nature 396, 416-417 (3 December 1998) | doi:10.1038/24743
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Signal transduction: New exchange, new target
Julian Downward1
The Ras superfamily of small guanine-nucleotide-binding (G) proteins controls many aspects of cellular behaviour, from proliferation and survival to morphology and membrane transport. Despite their varied effects, these proteins are regulated by a common mechanism — the opposing effects of stimulatory guanine-nucleotide-exchange factors (GEFs), which promote the uptake of fresh GTP to form an active, GTP-bound conformation, and inhibitory guanosine triphosphatase activating proteins, which stimulate hydrolysis of bound GTP to form the inactive, GDP-bound conformation.
- Julian Downward is in the Signal Transduction Laboratory, Imperial Cancer Research Fund, 44 Lincolns Inn Fields, London WC2A 3PX, UK.
e-mail: Email: downward@icrf.icnet.uk
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