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Nature 396, 317-318 (26 November 1998) | doi:10.1038/24503

Open Innovation Challenges

Muscle:  Support for the lever arm

A. F. Huxley1

On pages 380 and 383 of this issue, Suzuki et al.1 and Dobbie et al.2 describe investigations which support current ideas on the way in which changes in the cross-bridges between the myosin and actin filaments of muscle generate force or shortening.Length changes in muscle take place by relative sliding of two overlapping sets of filaments, composed respectively of myosin and actin.

  1. A. F. Huxley is at Trinity College, Cambridge CB2 1TQ, UK.