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Nature 396, 219-221 (19 November 1998) | doi:10.1038/24274

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Developmental neurobiology:  First class way to develop a brain

Jonathan Howard1 & Ian Thompson2

The major histocompatibility complex (MHC) is unambiguously part of the immune system. Generally speaking the immune system operates outside the blood-brain barrier, and this has been correlated with the belief that MHC glycoproteins are not expressed in the normal central nervous system.

  1. Jonathan Howard is at the Institute for Genetics, University of Cologne, Zülpicher Strasse 47, D-50674 Cologne, Germany.
    e-mail: Email: jonathan.howard@uni-koeln.de
  2. Ian Thompson is in the Department of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK.
    e-mail: Email: ian.thompson@physiol.ox.ac.uk