In many species, females have two X chromosomes whereas males have only one. To compensate for this difference, genes on the female X chromosomes are switched off. But how does an organism count how many chromosomes it has? A study in the nematode worm has just identified a protein called SEX-1, which represses a gene,xol-1, that is involved in both dosage compensation and sex determination.
- Amanda Swain
- Robin Lovell-Badge