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Nature 395, 846-847 (29 October 1998) | doi:10.1038/27557

Muscle proteins:  The clash in titin

Anthony R. Means1

According to Greek mythology, the Universe was formed and controlled by Titans — godlike giants who created order from chaos. In the same way, the most gigantic of all proteins, titin, brings order to sarcomeres (the contractile units of striated muscle) and organizes the machinery for condensation of chromosomes in dividing cells.

  1. Anthony R. Means is in the Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, North Carolina 27710, USA.
    e-mail: Email: means001@mc.duke.edu