Table of contents


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Opinion

Avoiding traditions that undermine Italy's potential p203

For years Italy's research council has suffered from scientific direction tainted by political considerations. Changes now in train carry risks that the next generation of Italian scientists will be similarly betrayed.

doi:10.1038/26047


Primakov's advantageous perspective p203

Russian science's survival requires the particular attention of the country's new prime minister.

doi:10.1038/26049


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News

Brussels seeks BSE diagnostic test to screen European cattle p205

Declan Butler

doi:10.1038/26051


Don't copy our clone, say Dolly scientists p205

Ehsan Masood

doi:10.1038/26054


Cuts 'could leave energy department brain-dead' p206

Colin Macilwain

doi:10.1038/26057


Biology teaching wins $90m boost from Howard Hughes institute p206

Colin Macilwain

doi:10.1038/26059


Human genome deadline cut by two years p207

Meredith Wadman

doi:10.1038/26061


Snowball comet idea refuses to melt away p207

Tony Reichhardt

doi:10.1038/26063


German poll could change research goals p208

Quirin Schiermeier and Alison Abbott

doi:10.1038/26066


Plan to pool part of Europe's science cash p208

Alison Abbott

doi:10.1038/26069


Foreign contracts 'Russia's only chance' p209

Carl Levitin and Ehsan Masood

doi:10.1038/26071


Hopes ride on manager with a scientist's mind p209

Carl Levitin

doi:10.1038/26074


US scientists call for fairer animal funding p210

Meredith Wadman

doi:10.1038/26076


Spain lets Latin America 'repay' debts by protecting environment p210

Xavier Bosch

doi:10.1038/26078


Clinton seeks refuge in calls for mentors to help minorities p211

Colin Macilwain

doi:10.1038/26081


Japanese institutes wary of increased autonomy p211

Asako Saegusa

doi:10.1038/26084


News in Brief p212

doi:10.1038/26086


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Correspondence

First shots fired in biological warfare p213

Mark Wheelis

doi:10.1038/26089


How Diana climbed the ratings at the zoo p213

Claire Carvell, Nicholas F. J. Inglis, Georgina M. Mace and Andy Purvis

doi:10.1038/26091


Top

News and Views

Worm holes and avian space-time p215

Kathryn Jeffery and John O'Keefe

doi:10.1038/26094


100 and 50 years ago p216

doi:10.1038/26097


Mathematics:  Magic squares cornered p216

Martin Gardner

doi:10.1038/26099


Bacterial infection:  For whom the bell tolls p217

Craig Gerard

doi:10.1038/26104


Nuclear physics:  Nuclear and subnuclear boiling p220

Frank Wilczek

doi:10.1038/26107


Mutagenesis:  Purposeful mutations p221

Myron F. Goodman

doi:10.1038/26111


Earth science:  Crack-up under the Pacific p223

Tim Lincoln

doi:10.1038/26114


Ribozymes:  How to make a nucleotide p223

Michael P. Robertson and Andrew D. Ellington

doi:10.1038/26117


Signal transduction:  Docking IkappaB kinases p225

Claus Scheidereit

doi:10.1038/26121


Daedalus:  Nuclear glue p226

David Jones

doi:10.1038/26124


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Science and Image

Mammary models p227

Clinicians screening patients for diseases such as breast cancer have to let a machine do much of the seeing for them. Theoretical modelling of the processes involved can help to ensure that reliable images are generated.

Martin Kemp

doi:10.1038/26126


Top

Scientific Correspondence

Mothers determine sexual preferences p229

Keith M. Kendrick, Michael R. Hinton, Khia Atkins, Martin A. Haupt and John D. Skinner

doi:10.1038/26129


All limbs are not the same p230

Bea Christen and Jonathan M. W. Slack

doi:10.1038/26133


Does vitamin C have a pro-oxidant effect? p231

Mark Levine, Rushad C. Daruwala, Jae B. Park, Steven C Rumsey and Yaohui Wang

doi:10.1038/26137


Does vitamin C have a pro-oxidant effect? p231

Henrik E. Poulsen, Allan Weimann, Jukka T. Salonen, Kristiina Nyyssönen, Steffen Loft, Jean Cadet, Thierry Douki and Jean-Luc Ravanat

doi:10.1038/26139


Reply:  Does vitamin C have a pro-oxidant effect? p232

Ian D. Podmore, Helen R. Griffiths, Karl E. Herbert, Nalini Mistry, Pratibha Mistry and Joseph Lunec

doi:10.1038/26141


Top

Book Reviews

The cowboys in Indian science p233

Pushpa M. Bhargava reviews Nonsense in Indian Science by Dilip M. Salwi

doi:10.1038/26143


Bodies of evidence p234

Bernard Wood reviews On the Fabric of the Human Body. Book One: The Bones and Cartilages by Andreas Vesalius, William Richardson and John Carman and The Complete Visible Human by Heinz-Otto Peitgen, Wilhelm Berghorn and Matthias Biel

doi:10.1038/26146


Undiplomatic immunity p235

Fred S. Rosen reviews The Generation of Diversity: Clonal Selection Theory and the Rise of Molecular Immunology by Scott H. Podolsky and Alfred Tauber

doi:10.1038/26150


Taking the mammoth steppes p236

Valerius Geist reviews Wildlife of the Tibetan Steppe by George B. Schaller

doi:10.1038/26152


Top

Articles

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a p237

Alicia A. Russo, Lily Tong, Jie-Oh Lee, Philip D. Jeffrey and Nikola P. Pavletich

doi:10.1038/26155


Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d p244

Deborah H. Brotherton, Venugopal Dhanaraj, Scott Wick, Leonardo Brizuela, Peter J. Domaille, Elena Volyanik, Xu Xu, Emilio Parisini, Brian O. Smith, Sharon J. Archer, Manuel Serrano, Stephen L. Brenner, Tom L. Blundell and Ernest D. Laue

doi:10.1038/26164


Top

Letters to Nature

Imaging circumstellar environments with a nulling interferometer p251

Philip M. Hinz, J. Roger P. Angel, William F. Hoffmann, Donald W. McCarthy, Jr, Patrick C. McGuire, Matt Cheselka, Joseph L. Hora and Neville J. Woolf

doi:10.1038/26172


Superconductivity in a two-dimensional electron gas p253

Philip Phillips, Yi Wan, Ivar Martin, Sergey Knysh and Denis Dalidovich

doi:10.1038/26179


Laminated fabrication of polymeric photovoltaic diodes p257

M. Granström, K. Petritsch, A. C. Arias, A. Lux, M. R. Andersson and R. H. Friend

doi:10.1038/26183


RNA-catalysed nucleotide synthesis p260

Peter J. Unrau and David P. Bartel

doi:10.1038/26193

See also: News and Views by Robertson & Ellington


Deep-ocean gradients in the concentration of dissolved organic carbon p263

Dennis A. Hansell and Craig A. Carlson

doi:10.1038/26200


Plastic deformation of silicate spinel under the transition-zone conditions of the Earth's mantle p266

Shun-ichiro Karato, Catherine Dupas-Bruzek and David C. Rubie

doi:10.1038/26206


Dynamic topography, plate driving forces and the African superswell p269

Carolina Lithgow-Bertelloni and Paul G. Silver

doi:10.1038/26212


Episodic-like memory during cache recovery by scrub jays p272

Nicola S. Clayton and Anthony Dickinson

doi:10.1038/26216

See also: News and Views by Jeffery & O'Keefe


Primary motor cortex is involved in bimanual coordination p274

O. Donchin, A. Gribova, O. Steinberg, H. Bergman and E. Vaadia

doi:10.1038/26220


Early-blind human subjects localize sound sources better than sighted subjects p278

N. Lessard, M. Paré, F. Lepore and M. Lassonde

doi:10.1038/26228


Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3 p281

Fumitaka Ushikubi, Eri Segi, Yukihiko Sugimoto, Takahiko Murata, Toshiyuki Matsuoka, Takuya Kobayashi, Hiroko Hizaki, Kazuhito Tuboi, Masato Katsuyama, Atsushi Ichikawa, Takashi Tanaka, Nobuaki Yoshida and Shuh Narumiya

doi:10.1038/26233


Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling p284

Ruey-Bing Yang, Melanie R. Mark, Alane Gray, Arthur Huang, Ming Hong Xie, Min Zhang, Audrey Goddard, William I. Wood, Austin L. Gurney and Paul J. Godowski

doi:10.1038/26239

See also: News and Views by Gerard


Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family p288

Luca Mastroberardino, Benjamin Spindler, Rahel Pfeiffer, Patrick J. Skelly, Jan Loffing, Charles B. Shoemaker and François Verrey

doi:10.1038/26246


IKAP is a scaffold protein of the IkappaB kinase complex p292

Lucie Cohen, William J. Henzel and Patrick A. Baeuerle

doi:10.1038/26254

See also: News and Views by Scheidereit


IKK-bold gamma is an essential regulatory subunit of the IkappaB kinase complex p297

David M. Rothwarf, Ebrahim Zandi, Gioacchino Natoli and Michael Karin

doi:10.1038/26261

See also: News and Views by Scheidereit


Signal-specific co-activator domain requirements for Pit-1 activation p301

Lan Xu, Robert M. Lavinsky, Jeremy S. Dasen, Sarah E. Flynn, Eileen M. McInerney, Tina-Marie Mullen, Thorsten Heinzel, Daniel Szeto, Edward Korzus, Riki Kurokawa, Aneel K. Aggarwal, David W. Rose, Christopher K. Glass and Michael G. Rosenfeld

doi:10.1038/26270


Erratum:  Evidence for the shikimate pathway in apicomplexan parasites p306

Fiona Roberts, Craig W. Roberts, Jennifer J. Johnson, Dennis E. Kyle, Tino Krell, John R. Coggins, Graham H. Coombs, Wilbur K. Milhous, Saul Tzipori, David J. P. Ferguson, Debopam Chakrabarti and Rima McLeod

doi:10.1038/26277


Erratum:  Phase-mapping of periodically domain-inverted LiNbO3 with coherent X-rays p306

Z. W. Hu, P. A. Thomas, A. Snigirev, I. Snigireva, A. Souvorov, P. G. R. Smith, G. W. Ross and S. Teat

doi:10.1038/26279


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