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Nature 395, 189-194 (10 September 1998) | doi:10.1038/26026;
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Apoptosis of CD8|[plus]| T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4
CD8-positive T cells are thought to play an important role in the control of infection by human immunodeficiency virus (HIV) as a result of their cytotoxic activity and by releasing soluble factors,. In AIDS patients, the absolute number of CD8|[plus]| T lymphocytes is decreased in peripheral blood, and their turnover rate is increased, suggesting that there is more cell renewal and cell death occurring.
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