Opinion

Young scientists deserve better of the system (yet again) p101

A high-level report on careers in the life sciences raises often-repeated worries about employment practices afflicting graduate students and postdoctoral researchers in the United States. A major rethink is required.

doi:10.1038/25794

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News

Jobs crisis sparks call for freeze in number of PhD students in US p103

Meredith Wadman

doi:10.1038/25796

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Retraining scheme could go Europe-wide p104

Quirin Schiermeier

doi:10.1038/25799

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Stock market crash threatens start-up biotech companies p104

Sally Lehrman

doi:10.1038/25801

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Neutrino study 'needs transatlantic effort' p105

Colin Macilwain

doi:10.1038/25803

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NASA charts Earth observation strategy p106

Tony Reichhardt

doi:10.1038/25806

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Call for Europe-wide public health agency p106

Declan Butler

doi:10.1038/25809

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Rapid shake-up at German health institute p107

Alison Abbott

doi:10.1038/25811

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Japanese science ministry expects large funding boost p107

Asako Saegusa

doi:10.1038/25814

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US unlikely to swallow plan for a food safety supremo p108

Meredith Wadman

doi:10.1038/25817

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Controversial appointment to SA council p108

Michael Cherry

doi:10.1038/25819

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Row in India over rules on animal experiments p108

K. S. Jayaraman

doi:10.1038/25822

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News in Brief p109

doi:10.1038/25824

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Correspondence

Toxic spill caught Spain off guard p110

Antonio Aparicio, Javier Escartín, Luis Santamaría and Pablo Valverde

doi:10.1038/25826

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Wacky, weird and scientifically illiterate p110

John Durant

doi:10.1038/25828

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Water, water, every weekend p110

Marc Abrahams

doi:10.1038/25830

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News and Views

River meanders in a tray p111

Gary Parker

doi:10.1038/25832

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Developmental biology:  Casting an eye over cyclopia p112

Patrick Blader and Uwe Strähle

doi:10.1038/25836

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Planetary science:  Ancient cosmic spherules p113

Don Brownlee

doi:10.1038/25840

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Population ecology:  Common rules for animals and plants p115

John D. Damuth

doi:10.1038/25843

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100 and 50 years ago p116

doi:10.1038/25845

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Mathematics:  Nonlinear modes of vibration p116

Ivar Ekeland

doi:10.1038/25847

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HIV:  Setting death in motion p117

Jean Claude Ameisen

doi:10.1038/25851

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Earth science:  The elusive coldfinger p119

George Helffrich

doi:10.1038/25854

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Daedalus:  Cruise micromissiles p120

David Jones

doi:10.1038/25857

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Science and Image

Audubon in action p121

Illustrators face a choice of truths: should they draw a creature in studio detail, or in its natural surroundings half hidden by shade? John James Audubon tried to capture the nature of birds in pictures backed by passionate prose.

Martin Kemp

doi:10.1038/25859

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Scientific Correspondence

Perceptual bias for rising tones p123

John G. Neuhoff

doi:10.1038/25862

First paragraph | Full Text | PDF (200K)

p14^ARF links the tumour suppressors RB and p53 p124

Stewart Bates, Andrew C. Phillips, Paula A. Clark, Francesca Stott, Gordon Peters, Robert L. Ludwig and Karen H. Vousden

doi:10.1038/25867

First paragraph | Full Text | PDF (219K) | Supplementary information

p19^ARF links the tumour suppressor p53 to Ras p125

Ignacio Palmero, Cristina Pantoja and Manuel Serrano

doi:10.1038/25870

First paragraph | Full Text | PDF (185K)

Impacts on Earth in the Late Triassic p126

Dennis V. Kent

doi:10.1038/25874

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Reply:  Impacts on Earth in the Late Triassic p126

John G. Spray

doi:10.1038/25876

First paragraph | Full Text | PDF (163K)

New Journals

On-line journals and financial fire walls p127

Stevan Harnad

doi:10.1038/25878

Abstract | Full Text | PDF (253K)

Journals index p128

doi:10.1038/25881

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Gathering the strands of thought p129

Martha J. Farah

doi:10.1038/25884

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Brains on call p129

Todd C. Holmes

doi:10.1038/25887

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Seen and heard p129

Peter Bryant

doi:10.1038/25889

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The chaotic psyche p130

H. Eugene Stanley

doi:10.1038/25891

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No waste of trees p130

David W. Schindler

doi:10.1038/25893

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Common ground among quagmires p131

Gilbert S. Hedstrom

doi:10.1038/25896

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Imperilled wetlands p131

Thomas J. Smith, III

doi:10.1038/25898

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Human interest stories p132

Michael Batty

doi:10.1038/25901

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Civil defence in the war against AIDS p132

Ralph J. DiClemente

doi:10.1038/25904

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Rapid response p133

Jeffrey M. Leiden

doi:10.1038/25907

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A fertile and dynamic sea p133

Brent L. Iverson

doi:10.1038/25909

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NO particular place to go p133

John Garthwaite

doi:10.1038/25911

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Venturing outside the laboratory p134

Patrick MacCarthy

doi:10.1038/25914

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A site for sore eyes p134

L. M. Brown

doi:10.1038/25916

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Digging up the recent past p135

Frans Verhaeghe

doi:10.1038/25919

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Free advice for experimenters p135

Laurie Goodman

doi:10.1038/25922

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Fuel for thought p135

A. C. McIntosh

doi:10.1038/25924

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Golden age journal p136

John Hogan

doi:10.1038/25926

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Living on the edge p136

John A. Baross

doi:10.1038/25928

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Article

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor- p137

Robert T. Nolte, G. Bruce Wisely, Stefan Westin, Jeffery E. Cobb, Millard H. Lambert, Riki Kurokawa, Michael G. Rosenfeld, Timothy M. Willson, Christopher K. Glass and Michael V. Milburn

doi:10.1038/25931

Abstract | Full Text | PDF (533K)

Letters to Nature

A mysterious dust clump in a disk around an evolved binary star system p144

M. Jura and J. Turner

doi:10.1038/25938

First paragraph | Full Text | PDF (235K)

Unaltered cosmic spherules in a 1.4-Gyr-old sandstone from Finland p146

Alexander Deutsch, Ansgar Greshake, Lauri J. Pesonen and Pekka Pihlaja

doi:10.1038/25943

First paragraph | Full Text | PDF (377K)

See also: News and Views by Brownlee

Magnetic trapping of calcium monohydride molecules at millikelvin temperatures p148

Jonathan D. Weinstein, Robert deCarvalho, Thierry Guillet, Bretislav Friedrich and John M. Doyle

doi:10.1038/25949

First paragraph | Full Text | PDF (281K)

Highly efficient phosphorescent emission from organic electroluminescent devices p151

M. A. Baldo, D. F. O'Brien, Y. You, A. Shoustikov, S. Sibley, M. E. Thompson and S. R. Forrest

doi:10.1038/25954

First paragraph | Full Text | PDF (295K)

Synthesis and organization of zeolite-like materials with three-dimensional helical pores p154

Thurman E. Gier, Xianhui Bu, Pingyun Feng and Galen D. Stucky

doi:10.1038/25960

First paragraph | Full Text | PDF (500K) | Supplementary information

Heterogeneous production of nitrous acid on soot in polluted air masses p157

M. Ammann, M. Kalberer, D. T. Jost, L. Tobler, E. Rössler, D. Piguet, H. W. Gäggeler and U. Baltensperger

doi:10.1038/25965

First paragraph | Full Text | PDF (310K)

Mantle discontinuities and temperature under the North American continental keel p160

Aibing Li, Karen M. Fischer, Michael E. Wysession and Timothy J. Clarke

doi:10.1038/25972

First paragraph | Full Text | PDF (364K)

See also: News and Views by Helffrich

Allometric scaling of plant energetics and population density p163

Brian J. Enquist, James H. Brown and Geoffrey B. West

doi:10.1038/25977

First paragraph | Full Text | PDF (273K)

See also: News and Views by Damuth

Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect p166

Yves Rossetti, Gilles Rode, Laure Pisella, Alessandro Farné, Ling Li, Dominique Boisson and Marie-Thérèse Perenin

doi:10.1038/25988

First paragraph | Full Text | PDF (260K) | Supplementary information

Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness p169

Ian H. Robertson, Jason B. Mattingley, Chris Rorden and Jon Driver

doi:10.1038/25993

First paragraph | Full Text | PDF (258K)

Increased number of synaptic GABA_A receptors underlies potentiation at hippocampal inhibitory synapses p172

Zoltan Nusser, Norbert Hájos, Peter Somogyi and Istvan Mody

doi:10.1038/25999

First paragraph | Full Text | PDF (1,355K)

Cloning of inv, a gene that controls left/right asymmetry and kidney development p177

Toshio Mochizuki, Yukio Saijoh, Ken Tsuchiya, Yasuaki Shirayoshi, Setsuo Takai, Choji Taya, Hiromichi Yonekawa, Kiyomi Yamada, Hiroshi Nihei, Norio Nakatsuji, Paul A. Overbeek, Hiroshi Hamada and Takahiko Yokoyama

doi:10.1038/26006

First paragraph | Full Text | PDF (477K)

Zebrafish organizer development and germ-layer formation require nodal-related signals p181

Benjamin Feldman, Michael A. Gates, Elizabeth S. Egan, Scott T. Dougan, Gabriela Rennebeck, Howard I. Sirotkin, Alexander F. Schier and William S. Talbot

doi:10.1038/26013

First paragraph | Full Text | PDF (571K)

See also: News and Views by Blader & Strähle

Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling p185

Karuna Sampath, Amy L. Rubinstein, Abby M. S. Cheng, Jennifer O. Liang, Kimberly Fekany, Lilianna Solnica-Krezel, Vladimir Korzh, Marnie E. Halpern and Christopher V. E. Wright

doi:10.1038/26020

First paragraph | Full Text | PDF (474K)

See also: News and Views by Blader & Strähle

Apoptosis of CD8⁺ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4 p189

Georges Herbein, Ulrich Mahlknecht, Franak Batliwalla, Peter Gregersen, Todd Pappas, John Butler, William A. O'Brien and Eric Verdin

doi:10.1038/26026

First paragraph | Full Text | PDF (319K)

See also: News and Views by Ameisen

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity p194

Margareta Nikolic, Margaret M. Chou, Wange Lu, Bruce J. Mayer and Li-Huei Tsai

doi:10.1038/26034

First paragraph | Full Text | PDF (399K)

Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators p199

Stefan Westin, Riki Kurokawa, Robert T. Nolte, G. Bruce Wisely, Eileen M. McInerney, David W. Rose, Michael V. Milburn, Michael G. Rosenfeld and Christopher K. Glass

doi:10.1038/26040

First paragraph | Full Text | PDF (319K)