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Nature 394, 829-831 (27 August 1998) | doi:10.1038/29642

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Translation:  Cinderella factors have a ball

Richard J. Jackson1

When ribosomes synthesize proteins by translating messenger RNA, they must start the decoding at the correct point on the mRNA. In eukaryotes this is achieved by a scanning mechanism: the small (40S) ribosomal subunit binds to the mRNA near the 5' cap, and then scans in a 5'-3' direction until it encounters the first AUG triplet, which normally serves as the site for initiation of translation1.

  1. Richard J. Jackson is in the Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.
    e-mail: Email: rjj@mole.bio.cam.ac.uk