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Nature 394, 527-528 (6 August 1998) | doi:10.1038/28961

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Cancer:  Proteases — invasion and more

Dylan R. Edwards1 & Gillian Murphy1

The June AACR/APMIS conference*on 'proteases and protease inhibitors in cancer' provided an opportunity to take a good look at the importance of these proteins in cancer biology, particularly for functions other than cellular invasion1. The conference came at an appropriate time, with booming interest in angiogenesis (the formation of new blood vessels) as a therapeutic target and with first-generation synthetic matrix metalloproteinase inhibitors (MMPIs), such as British Biotech's marimastat, hitting the clinic.

  1. Dylan R. Edwards and Gillian Murphy are in the School of Biological Sciences, University of East Anglia, Norwich, Norfolk NR4 7TJ, UK.
    e-mails: Email: dylan.edwards@uea.ac.uk
    Email: g.murphy@uea.ac.uk