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Nature 394, 421-422 (30 July 1998) | doi:10.1038/28738

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Immunology:  The original sin of killer T cells

Andrew J. McMichael1

The phrase 'original antigenic sin' was first used to describe the antibody response to influenza virus. After an initial infection, reinfection (or vaccination) with a new strain of the virus boosted the concentration of antibodies specific for the earlier infecting strain1,2.

  1. Andrew J. McMichael is at the Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.
    e-mail: Email: amcmichael@hammer.imm.ox.ac.uk