Table of contents
Volume 393 Number 6682 pp195-289
Opinion
A challenge to genetic transparency p195
Those engaged in the publicly funded effort to sequence the human genome should look on their new rival as healthy competition. But they will also need to protect the standards they have fought hard to establish.
doi:10.1038/30294
News
India's nuclear tests meet with domestic praise and protests p197
K. S. Jayaraman
doi:10.1038/30296
Nuclear tests were a culmination of twenty-five years of planning p197
K. S. Jayaraman
doi:10.1038/30299
Disappointment as New Zealand's budget gives science 'inflation' p198
Peter Pockley
doi:10.1038/30301
First underground nuclear waste store set to open in US p199
Colin Macilwain
doi:10.1038/30303
Clinton 'is failing to honour pledge on AIDS vaccine' p199
Colin Macilwain
doi:10.1038/30305
Japan's emissions bill comes under fire p199
Asako Saegusa
doi:10.1038/30307
Europe's life patent moratorium may go ... p200
Alison Abbott
doi:10.1038/30309
... as US office claims right to rule on morality p200
Meredith Wadman
doi:10.1038/30312
Genome effort 'still in need of support' p201
David Dickson and Meredith Wadman
doi:10.1038/30314
British funding boost is Wellcome news p201
David Dickson
doi:10.1038/30317
UN reaches deal on biodiversity science p202
Ehsan Masood
doi:10.1038/30319
Japan's quake strategy urged to switch to long-term forecasting p202
Asako Saegusa
doi:10.1038/30321
France seeks scientific entrepreneurs p203
Declan Butler
doi:10.1038/30324
Report released on INSERM laboratory p203
Declan Butler
doi:10.1038/30327
Correspondence
Swiss democracy has its advantages p205
John C. Badoux, President, David Hunkeler, Rosmarie Waldner and Henry T. Greely
doi:10.1038/30332
Loopholes exploited in whaling regulation p206
Sidney J. Holt
doi:10.1038/30334
We aim to refresh science, not to rebel p206
Vincenzo De Laurenzi, Michael Hahne, Henning Walczak and Jan Paul Medema
doi:10.1038/30336
BSE coordinator should have been full-time job p206
F. Brown
doi:10.1038/30338
News and Views
Sound grounds for computing dendrites p207
Idan Segev
doi:10.1038/30340
Climate change: The carbon equation p208
David S. Schimel
doi:10.1038/30344
Molecular neuroendocrinology: Working backwards to find answers p211
Jean-Claude Meunier
doi:10.1038/30347
100 and 50 years ago p212
doi:10.1038/30350
Thermodynamics: Size is everything p212
R. Stephen Berry
doi:10.1038/30352
Behavioural ecology: Cuckoos beg the answer p213
Rory Howlett
doi:10.1038/30354
Neutron stars: A star powered by magnetism p215
S. R. Kulkarni and Christopher Thompson
doi:10.1038/30357
Neurobiology: Knowing where you're going p216
Alison Mitchell
doi:10.1038/30360
Cervical cancer: Papillomavirus and p53 p217
Harald zur Hausen
doi:10.1038/30363
Daedalus: Silent flight p217
David Jones
doi:10.1038/30365
Obituary: Jean Rouxel (1935-98) p218
Michel Pouchard
doi:10.1038/30367
Science and Image
Hyde's horrors p219
Can you tell a criminal from the look of his face? The "downright detestable" appearance of Robert Louis Stevenson's evil Mr Hyde stands in the same tradition as the images used by Darwin in his work on pathognomics.
Martin Kemp
doi:10.1038/30370
Scientific Correspondence
Human gene for physical performance p221
H. E. Montgomery, R. Marshall, H. Hemingway, S. Myerson, P. Clarkson, C. Dollery, M. Hayward, D. E. Holliman, M. Jubb, M. World, E. L. Thomas, A. E. Brynes, N. Saeed, M. Barnard, J. D. Bell, K. Prasad, M. Rayson, P. J. Talmud and S. E. Humphries
doi:10.1038/30374
First paragraph | Full Text | PDF (196K)
Meteoritic oxide grain from supernova found p222
L. R. Nittler, C. M. O'D. Alexander, J. Wang and X. Gao
doi:10.1038/30377
First paragraph | Full Text | PDF (232K)
Polarization vision helps detect transparent prey p222
Nadav Shashar, Roger T. Hanlon and Anne deM. Petz
doi:10.1038/30380
First paragraph | Full Text | PDF (232K)
Ultradry seed storage cuts cost of gene bank p223
Guang-Hua Zheng, Xin-Ming Jing and Kar-Ling Tao
doi:10.1038/30383
First paragraph | Full Text | PDF (322K)
Book Reviews
China's long march into the space age p225
Roy Gibson reviews The Chinese Space Programme: From Conception to Future Capabilities by Brian Harvey
doi:10.1038/30386
Lost for words p226
Philip T. Smith reviews Why Our Children Can't Read and What We Can Do About It by Diane McGuinness
doi:10.1038/30389
Some like it hot p227
Andrew R. Cossins reviews Life on the Edge: Amazing Creatures Thriving in Extreme Environments by Michael Gross
doi:10.1038/30391
Water colours p227
doi:10.1038/30393
Designer chemistry p228
Pierre Laszlo
doi:10.1038/30396
New Journals p228
doi:10.1038/30398
Article
Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer p229
The E6 oncoprotein derived from tumour-associated human papillomaviruses (HPVs) binds to and induces the degradation of the cellular tumour-suppressor protein p53. A common polymorphism that occurs in the p53 amino-acid sequence results in the presence of either a proline or an arginine at position 72. The effect of this polymorphism on the susceptibility of p53 to E6-mediated degradation has been investigated and the arginine form of p53 was found to be significantly more susceptible than the proline form. Moreover, allelic analysis of patients with HPV-associated tumours revealed a striking overrepresentation of homozygous arginine-72 p53 compared with the normal population, which indicated that individuals homozygous for arginine 72 are about seven times more susceptible to HPV-associated tumorigenesis than heterozygotes. The arginine-encoding allele therefore represents a significant risk factor in the development of HPV-associated cancers.
Alan Storey, Miranda Thomas, Ann Kalita, Catherine Harwood, Daniela Gardiol, Fiamma Mantovani, Judith Breuer, Irene M. Leigh, Greg Matlashewski and Lawrence Banks
doi:10.1038/30400
See also: News and Views by zur Hausen
Letters to Nature
An X-ray pulsar with a superstrong magnetic field in the soft 
-ray repeater SGR1806 - 20 p235
C. Kouveliotou, S. Dieters, T. Strohmayer, J. van Paradijs, G. J. Fishman, C. A. Meegan, K. Hurley, J. Kommers, I. Smith, D. Frail and T. Murakami
doi:10.1038/30410
First paragraph | Full Text | PDF (245K)
See also: News and Views by Kulkarni & Thompson
Irregular variations in the melting point of size-selected atomic clusters p238
Martin Schmidt, Robert Kusche, Bernd von Issendorff and Hellmut Haberland
doi:10.1038/30415
First paragraph | Full Text | PDF (266K)
See also: News and Views by Berry
Carbon nanotubes as long ballistic conductors p240
C. T. White and T. N. Todorov
doi:10.1038/30420
First paragraph | Full Text | PDF (403K)
Intertwined symmetry of the magnetic modulation and the flux-line lattice in the superconducting state of TmNi2B2C p242
M. R. Eskildsen, K. Harada, P. L. Gammel, A. B. Abrahamsen, N. H. Andersen, G. Ernst, A. P. Ramirez, D. J. Bishop, K. Mortensen, D. G. Naugle, K. D. D. Rathnayaka and P. C. Canfield
doi:10.1038/30447
First paragraph | Full Text | PDF (275K)
Simulated response of the ocean carbon cycle to anthropogenic climate warming p245
Jorge L. Sarmiento, Tertia M. C. Hughes, Ronald J. Stouffer and Syukuro Manabe
doi:10.1038/30455
First paragraph | Full Text | PDF (288K)
See also: News and Views by Schimel
Dynamic responses of terrestrial ecosystem carbon cycling to global climate change p249
Mingkui Cao and F. Ian Woodward
doi:10.1038/30460
First paragraph | Full Text | PDF (417K)
See also: News and Views by Schimel
Mineralogy and dynamics of a pyrolite lower mantle p252
S. E. Kesson, J. D. Fitz Gerald and J. M. Shelley
doi:10.1038/30466
First paragraph | Full Text | PDF (395K)
Ichthyosaurian relationships illuminated by new primitive skeletons from Japan p255
Ryosuke Motani, Nachio Minoura and Tatsuro Ando
doi:10.1038/30473
First paragraph | Full Text | PDF (508K) | Supplementary information
Dynamics of North American breeding bird populations p257
Timothy H. Keitt and H. Eugene Stanley
doi:10.1038/30478
First paragraph | Full Text | PDF (302K)
Herbicide resistance caused by spontaneous mutation of the cytoskeletal protein tubulin p260
Richard G. Anthony, Teresa R. Waldin, John A. Ray, Simon W. J. Bright and Patrick J. Hussey
doi:10.1038/30484
First paragraph | Full Text | PDF (408K)
An X-linked gene with a degenerate Y-linked homologue in a dioecious plant p263
David S. Guttman and Deborah Charlesworth
doi:10.1038/30492
First paragraph | Full Text | PDF (328K)
Evidence for striatal dopamine release during a video game p266
M. J. Koepp, R. N. Gunn, A. D. Lawrence, V. J. Cunningham, A. Dagher, T. Jones, D. J. Brooks, C. J. Bench and P. M. Grasby
doi:10.1038/30498
First paragraph | Full Text | PDF (269K)
The role of dendrites in auditory coincidence detection p268
Hagai Agmon-Snir, Catherine E. Carr and John Rinzel
doi:10.1038/30505
First paragraph | Full Text | PDF (292K)
See also: News and Views by Segev
A prolactin-releasing peptide in the brain p272
Shuji Hinuma, Yugo Habata, Ryo Fujii, Yuji Kawamata, Masaki Hosoya, Shoji Fukusumi, Chieko Kitada, Yoshinori Masuo, Tsuneo Asano, Hirokazu Matsumoto, Masahiro Sekiguchi, Tsutomu Kurokawa, Osamu Nishimura, Haruo Onda and Masahiko Fujino
doi:10.1038/30515
First paragraph | Full Text | PDF (407K)
See also: News and Views by Meunier
Elastin is an essential determinant of arterial morphogenesis p276
Dean Y. Li, Benjamin Brooke, Elaine C. Davis, Robert P. Mecham, Lise K. Sorensen, Beth B. Boak, Ernst Eichwald and Mark T. Keating
doi:10.1038/30522
First paragraph | Full Text | PDF (682K)
Protein-primed RNA synthesis by purified poliovirus RNA polymerase p280
Aniko V. Paul, Jacques H. van Boom, Dmitri Filippov and Eckard Wimmer
doi:10.1038/30529
First paragraph | Full Text | PDF (345K)
Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation p284
Hiroaki Kawasaki, Richard Eckner, Tso-Pang Yao, Kazunari Taira, Robert Chiu, David M. Livingston and Kazunari K. Yokoyama
doi:10.1038/30538
First paragraph | Full Text | PDF (477K)
