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Nature 393, 217 (21 May 1998) | doi:10.1038/30363

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Cervical cancer:  Papillomavirus and p53

Harald zur Hausen1

Certain types of human papillomavirus (HPV) are linked with most cases of cervical cancer, and also with vulval, penile and perianal cancers1,2. Although viral oncogenes are obviously pivotal in the development of cancer, merely expressing them is not enough — either for immortalization of cultured human cells, or for malignant conversion.

  1. Harald zur Hausen is at the Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    e-mail: Email: zurhausen@dkft-heidelberg.de