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Nature 393, 114-115 (14 May 1998) | doi:10.1038/30097

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Gene expression:  Transcription sans TBP

Lynne M. Apone1 & Michael R. Green1

In the field of transcription there is little room for dogmatism — principles that were once deemed sacrosanct can be violated with impunity. The latest example of this is illustrated on page 187 of this issue, where Wieczorek et al.1 show that a factor that was thought to be essential for transcription, the TATA-binding protein (TBP), is, at least under some circumstances, dispensable.

  1. Lynne M. Apone and Michael R. Green are in the Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical Center, 373 Plantation Street, Worcester, Massachusetts 01605, USA.
    e-mail: Email: michael.green@ummed.edu