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Nature 392, 869-870 (30 April 1998) | doi:10.1038/31816

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Neuropharmacology:  Premenstrual steroids?

Karen T. Britton1 & George F. Koob2

Premenstrual syndrome (PMS) is a disorder that is characterized by depression, anxiety and mood swings. It regularly occurs during the last week of the luteal phase of the menstrual cycle, two weeks before menses1,2, and the symptoms have a considerable negative effect on the social and occupational lives of severely afflicted women.

  1. Karen T. Britton is in the Department of Psychiatry, Veterans Administration Medical Center and University of California, San Diego, California 92161, USA.
    e-mail: Email: kbritton@ucsd.edu
  2. George F. Koob is in the Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
    e-mail: Email: gkoob@scripps.edu