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Nature 392, 611-614 (9 April 1998) | doi:10.1038/33429;

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Role of Rel/NF-|[kappa]|B transcription factors during the outgrowth of the vertebrate limb

The development of the vertebrate limb serves as an amenable system for studying signaling pathways that lead to tissue patterning and proliferation. Limbs originate as a consequence of a differential growth of cells from the lateral plate mesoderm at specific axial levels.

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