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Nature 392, 553-554 (9 April 1998) | doi:10.1038/33293

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Signal transduction:  Taking the Rap

Christopher J. Marshall1

Treatment of the phaeochromocytoma cell line PC12 with nerve growth factor (NGF) leads to differentiation of the cells into a phenotype that resembles sympathetic neurons. Yet treatment with other growth factors, such as epidermal growth factor (EGF), does not.

  1. Christopher J. Marshall is at the Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.
    e-mail: Email: chrism@ic.ac.uk