Scientific Correspondence
Nature 392, 447 (2 April 1998) | doi:10.1038/33040
Domains of rasGAP and rhoGAP are related
Benjamin Bax1
Guanine-nucleotide-binding (G) proteins are 'switched off' by the hydrolysis of their bound GTP. The GTP bound to the G protein Ras is hydrolysed intrinsically at a very slow rate1, so, in vivo, Ras is turned off by GTPase-activating proteins (GAPs). The structures of GTPase-activating domains (GAP domains), which usually occur as parts of larger proteins, indicate that the Ras and Rho families of small G proteins and their GAPs evolved in parallel.
-
Department of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK
e-mail: Email: b.bax@mail.cryst.bbk.ac.uk