Opinion

Perils in free market genomics p315

Scientific and medical enthusiasm for the potential contributions of germline gene therapy must not obscure the need for detailed debate about its potential consequences — or for careful monitoring and sensitive regulation.

doi:10.1038/32717

Full Text | PDF (102K)

All hands on deck? p315

Effective maritime research requires collaboration, but the case for a European agency has still to be made.

doi:10.1038/32719

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News

Germline gene therapy 'must be spared excessive regulation' p317

Meredith Wadman

doi:10.1038/32721

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European states outlaw permanent changes p317

Meredith Wadman

doi:10.1038/32724

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Review could speed up German grants p318

Quirin Schiermeier

doi:10.1038/32726

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Russian church and scientists lay revolutionary quarrels to rest p318

Carl Levitin

doi:10.1038/32728

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MAFF in a stew over food research plans p319

Ehsan Masood

doi:10.1038/32731

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Novartis goes public with fraud dismissal p319

Quirin Schiermeier

doi:10.1038/32734

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India awards science portfolio to advocate of nuclear arms p320

K S Jayaraman

doi:10.1038/32736

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New Zealand's universities face 'privatization' bid p320

Peter Pockley

doi:10.1038/32738

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Japan's NASDA under fire on launch failure p321

Asako Saegusa

doi:10.1038/32741

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Set clear priorities to win surplus cash, Canada's scientists told p321

David Spurgeon

doi:10.1038/32744

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Ecologists row over lobbying strategy p322

Tony Reichhardt

doi:10.1038/32746

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Telescope users win respite from mobile phone interference p322

Tony Reichhardt

doi:10.1038/32748

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Politicians support maritime agency plans p323

Declan Butler

doi:10.1038/32751

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News in Brief p324

doi:10.1038/32754

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Correspondence

Patents, ownership and sovereignty p325

Peter Glasner, Harry Rothman and David Wood

doi:10.1038/32756

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Send not to know... p325

Robert W. Old

doi:10.1038/32759

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Commentary

Lifting the veil on perverse subsidies p327

doi:10.1038/32761

Abstract | Full Text | PDF (248K)

News and Views

Giant submarine landslides p329

Euan G. Nisbet and David J. W. Piper

doi:10.1038/32765

Full Text | PDF (893K)

Human physiology:  Life without leptin p330

Stephen O'Rahilly

doi:10.1038/32769

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Liquid crystals:  Out of the groove p331

Jos van Haaren

doi:10.1038/32771

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100 and 50 years ago p333

doi:10.1038/32774

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Pharmacology:  Substance P equals pain substance? p334

Leslie Iversen

doi:10.1038/32776

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Climate forecasting:  Outlook — probably wet in parts p334

Philip Newton

doi:10.1038/32778

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Palaeoclimatology:  Icing the North Atlantic p335

Richard B. Alley

doi:10.1038/32781

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Daedalus:  Crookes flies high p337

David Jones

doi:10.1038/32784

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Obituary:  Erik Jarvik (1907-98) p338

Philippe Janvier

doi:10.1038/32786

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News and Views Feature

Microbial genomes opened up p339

Russell F. Doolittle

doi:10.1038/32789

Full Text | PDF (217K)

Art and Science

Turner's Trinity p343

Turner is famous as a master of the use of primary colours to depict light in painting. What is less well known is that he was also a student of the science behind that art.

Martin Kemp

doi:10.1038/32794

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Scientific Correspondence

Genes for asymmetry easily overruled p345

Alan W. Harvey

doi:10.1038/32798

First paragraph | Full Text | PDF (223K)

A triploblast origin for Myxozoa? p346

C. L. Anderson, E. U. Canning and Beth Okamura

doi:10.1038/32801

First paragraph | Full Text | PDF (210K)

Coral provides way to age deep water p347

A. Mangini, M. Lomitschka, R. Eichstädter, N. Frank, S. Vogler, G. Bonani, I. Hajdas and J. Patzold

doi:10.1038/32804

First paragraph | Full Text | PDF (249K)

Contradictions of slate formation resolved? p348

Ben A. van der Pluijm, Nei-Che Ho, Donald R. Peacor and Richard J. Merriman

doi:10.1038/32810

First paragraph | Full Text | PDF (213K)

Book Reviews

American voyeurs in Paris p349

W. F. Bynum

doi:10.1038/32813

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Feature selection p350

Stuart Sutherland

doi:10.1038/32817

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Attention! p350

doi:10.1038/32819

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After Simpson p350

Jean-Louis Hartenberger

doi:10.1038/32821

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Jargon and icons p351

Christopher Surridge

doi:10.1038/32824

Full Text | PDF (397K)

Making sense of the stars p352

doi:10.1038/32826

Full Text | PDF (327K)

New editions p352

doi:10.1038/32829

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Article

The complete genome of the hyperthermophilic bacterium Aquifex aeolicus p353

Gerard Deckert, Patrick V. Warren, Terry Gaasterland, William G. Young, Anna L. Lenox, David E. Graham, Ross Overbeek, Marjory A. Snead, Martin Keller, Monette Aujay, Robert Huber, Robert A. Feldman, Jay M. Short, Gary J. Olsen and Ronald V. Swanson

doi:10.1038/32831

Abstract | Full Text | PDF (472K)

Letters to Nature

The seeds of rich galaxy clusters in the Universe p359

F. Governato, C. M. Baugh, C. S. Frenk, S. Cole, C. G. Lacey, T. Quinn and J. Stadel

doi:10.1038/32837

First paragraph | Full Text | PDF (389K)

Negative Poisson's ratios as a common feature of cubic metals p362

Ray H. Baughman, Justin M. Shacklette, Anvar A. Zakhidov and Sven Stafström

doi:10.1038/32842

First paragraph | Full Text | PDF (297K) | Supplementary information

Voltage-dependent anchoring of a nematic liquid crystal on a grating surface p365

G. P. Bryan-Brown, C. V. Brown, I. C. Sage and V. C. Hui

doi:10.1038/32849

First paragraph | Full Text | PDF (249K)

See also: News and Views by van Haaren

Polymeric emulsifiers based on reversible formation of hydrophobic units p367

Arvind M. Mathur, Bernhard Drescher, Alec B. Scranton and John Klier

doi:10.1038/32856

First paragraph | Full Text | PDF (319K)

Global seasonal rainfall forecasts using a coupled ocean–atmosphere model p370

T. N. Stockdale, D. L. T. Anderson, J. O. S. Alves and M. A. Balmaseda

doi:10.1038/32861

First paragraph | Full Text | PDF (442K)

See also: News and Views by Newton

Ice-sheet variability around the North Atlantic Ocean during the last deglaciation p373

A. Marshall McCabe and Peter U. Clark

doi:10.1038/32866

First paragraph | Full Text | PDF (444K)

See also: News and Views by Alley

Low-sea-level emplacement of a very large Late Pleistocene 'megaturbidite' in the western Mediterranean Sea p377

R. G. Rothwell, J. Thomson and G. Kähler

doi:10.1038/32871

First paragraph | Full Text | PDF (451K)

See also: News and Views by Nisbet & Piper

Optimal clutch size and conspecific brood parasitism p380

Bruce E. Lyon

doi:10.1038/32878

First paragraph | Full Text | PDF (250K)

Exceptional soft-tissue preservation in a theropod dinosaur from Italy p383

Cristiano Dal Sasso and Marco Signore

doi:10.1038/32884

First paragraph | Full Text | PDF (788K)

Somatosensory discrimination based on cortical microstimulation p387

Ranulfo Romo, Adrián Hernández, Anótonio Zainos and Emilio Salinas

doi:10.1038/32891

First paragraph | Full Text | PDF (294K)

Primary afferent tachykinins are required to experience moderate to intense pain p390

Yu Qing Cao, Patrick W. Mantyh, Elaine J. Carlson, Anne-Marie Gillespie, Charles J. Epstein and Allan I. Basbaum

doi:10.1038/32897

First paragraph | Full Text | PDF (343K)

See also: News and Views by Iversen

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P p394

Carmen De Felipe, Juan F. Herrero, John A. O'Brien, James A. Palmer, Christopher A. Doyle, Andrew J. H. Smith, Jennifer M. A. Laird, Carlos Belmonte, Fernando Cervero and Stephen P. Hunt

doi:10.1038/32904

First paragraph | Full Text | PDF (302K) | Supplementary information

See also: News and Views by Iversen

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction p398

Karine Clément, Christian Vaisse, Najiba Lahlou, Sylvie Cabrol, Veronique Pelloux, Dominique Cassuto, Micheline Gourmelen, Christian Dina, Jean Chambaz, Jean-Marc Lacorte, Arnaud Basdevant, Pierre Bougnères, Yves Lebouc, Philippe Froguel and Bernard Guy-Grand

doi:10.1038/32911

First paragraph | Full Text | PDF (361K)

See also: News and Views by O'Rahilly

E-cadherin germline mutations in familial gastric cancer p402

Parry Guilford, Justin Hopkins, James Harraway, Maybelle McLeod, Ngahiraka McLeod, Pauline Harawira, Huriana Taite, Robin Scoular, Andrew Miller and Anthony E. Reeve

doi:10.1038/32918

First paragraph | Full Text | PDF (337K)

Stabilization of wild-type p53 by hypoxia-inducible factor 1 p405

Won G. An, Meera Kanekal, M. Celeste Simon, Emin Maltepe, Mikhail V. Blagosklonny and Leonard M. Neckers

doi:10.1038/32925

First paragraph | Full Text | PDF (372K)

Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction p408

J. S. Boyle, J. L. Brady and A. M. Lew

doi:10.1038/32932

First paragraph | Full Text | PDF (285K)

Rhodopsin-family receptors associate with small G proteins to activate phospholipase D p411

Rory Mitchell, Derek McCulloch, Eve Lutz, Melanie Johnson, Chris MacKenzie, Myles Fennell, George Fink, Wei Zhou and Stuart C. Sealfon

doi:10.1038/32937

First paragraph | Full Text | PDF (251K)

New on the Market

To market, to market... p415

This roundup of recently announced products includes isoelectric focusing plates, filter capsules and electrophoresis kits for separations, as well as lamps, sample wheels and instruments for spectroscopy.

compiled by Brendan Horton from information provided by the manufacturers.

doi:10.1038/32943

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Careers and Recruitment

Action at the edges in cancer research p417

Potter Wickware

doi:10.1038/32945

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Seeking the bigger picture in the puzzle p417

Brendan Horton

doi:10.1038/32948

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Visionaries seek UK national strategy p419

Alison Mitchell

doi:10.1038/32952

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Research opportunities at the cancer charities p419

Alison Mitchell

doi:10.1038/32955

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Therapeutics: a glimpse of the future p420

Owen Goldring

doi:10.1038/32957

Full Text | PDF (135K)