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Nature 392, 223-224 (19 March 1998) | doi:10.1038/32520
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A checkpoint on the road to cancer
Terry L. Orr-Weaver1 & Robert A. Weinberg1
Mutations that disrupt a cell-division checkpoint, thereby causing alterations in chromosome number, have been identified in cancer cells. The accompanying increase in mutability helps to explain how tumours acquire large numbers of mutant genes during their development.
- Terry L. Orr-Weaver and Robert A. Weinberg are at the Whitehead Institute for Biomedical Research and the Department of Biologya, MIT, Cambridge, Massachusetts 02142-1479, USA.
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