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Nature 391, 846-847 (26 February 1998) | doi:10.1038/35998

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Diabetes:  A signal for bold beta-cell failure

Joseph Avruch1

Human type 2 diabetes is almost always accompanied by defects in both the responsiveness to insulin (which is commonly called insulin resistance) and the secretion of insulin. The result is hyperglycaemia — an excess of glucose in the bloodstream.

  1. Joseph Avruch is in the Diabetes Unit, Department of Medicine, and the Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA.
    e-mail: Email: avruch@helix.mgh.harvard.edu