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From the following article:

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery, Deborah J. Burks, Jian-Ming Ren, Stephen Previs, Yitao Zhang, Dolores Bernal, Sebastian Pons, Gerald I. Shulman, Susan Bonner-Weir and Morris F. White

Nature 391, 900-904(26 February 1998)

doi:10.1038/36116

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Figure 1

Gene targeting of the IRS-2 locus.

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Figure 2

Fasting blood glucose and glucose-tolerance test, fasting insulin levels and insulin-tolerance test, and in vivo glucose disposal and hepatic glucose production.

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Figure 3

Expression and insulin-stimulated tyrosine phosphorylation of the insulin receptor (IR), insulin-stimulated activation of PI(3)K and IRS association with p85, and expression of PI(3)K adaptor subunits in the liver and muscle of wild-type (WT), IRS-1-/- and IRS-2-/- mice.

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Figure 4

Islet morphology and analysis of beta-cell mass in IRS-2-/-, IRS-1-/- and wild-type mice, and expression of IRS-2 in islets of wild-type and IRS-2-/- mice.

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