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Nature 391, 748-749 (19 February 1998) | doi:10.1038/35761
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Neural patterning Deconstructing the organizer
A. Ruiz i Altaba1
Modern understanding of animal development depends on the concept of the 'organizer' — a group of cells which sends signals that induce distinct fates in neighbouring cells, resulting in spatial patterning1 (see box). For example, initial patterning of the central nervous system, along the anteroposterior (forebrain-to-spinal-cord) axis seems to depend on signals from the organizer2.
- A. Ruiz i Altaba is at the Skirball Institute, Developmental Genetics Program, NYU Medical Center, 540 First Avenue, New York, New York 10016, USA.
e-mail: Email: ria@saturn.med.nyu.edu
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