Opinion

How to relax with a hamburger p309

A proposed new agency is a welcome first step towards a recovery of public trust in food. But an unsatisfactory history and unresolved questions necessitate continuing vigilance.

doi:10.1038/34708

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Halt the xeno-bandwagon p309

Xenotransplantation's risks make a moratorium essential.

doi:10.1038/34710

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News

Universities warned on danger of new links to weapons labs p311

Colin Macilwain

doi:10.1038/34712

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Ban on access for foreign scientists poses a problem for partnership p311

Colin Macilwain

doi:10.1038/34716

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Switzerland seeks to head off ban on use of transgenic animals p312

Quirin Schiermeier

doi:10.1038/34718

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Japan gears up to debate brake on human cloning p313

Asako Saegusa

doi:10.1038/34720

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UK's food standards agency will report to health minister p313

Ehsan Masood

doi:10.1038/34722

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'Group debate' urged for gene studies p314

Meredith Wadman

doi:10.1038/34725

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SUSI digs deep for distant galaxies p314

doi:10.1038/34727

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Poll reveals backing for xenotransplants p315

Declan Butler

doi:10.1038/34730

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FDA 'fails to keep track of transplant patients' p315

Meredith Wadman

doi:10.1038/34733

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Brussels' subsidy to shift away from infrastructure p316

Alison Abbott

doi:10.1038/34735

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Framework themes grow to four, but budget stays the same p316

Alison Abbott

doi:10.1038/34737

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Advances in neuroscience 'may threaten human rights' p316

Declan Butler

doi:10.1038/34739

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World Bank renews its support for Brazil p317

Ricardo Bonalume

doi:10.1038/34742

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Nanjing tops China's league for international science citations p317

David Swinbanks

doi:10.1038/34744

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News in Brief p318

doi:10.1038/34747

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Briefings

Last chance to stop and think on risks of xenotransplants p320

US regulations are soon to be released allowing trials of animal-to-human transplants. Some feel this is premature, arguing that the risks of creating human diseases remain uncertain, and more preclinical research is needed.

doi:10.1038/34749

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UK ahead in moves to regulate p321

doi:10.1038/34755

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Confronting the risks of 'xeno-havens' p322

doi:10.1038/34758

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Primate risks 'still going unheeded' p324

doi:10.1038/34760

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Alternative ways of meeting demand p325

doi:10.1038/34763

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Correspondence

Call for moratorium on xenotransplants p326

Fritz H. Bach and Harvey V. Fineberg

doi:10.1038/34766

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Equal opportunities in Canada p326

Henry G. Friesen

doi:10.1038/34768

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Kuhnian pastiche p326

German E. Berrios

doi:10.1038/34770

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Commentary

Transgenic pigs and virus adaptation p327

doi:10.1038/34772

Abstract | Full Text | PDF (234K)

News and Views

News of chews: the optimization of mastication p329

R. McNeill Alexander

doi:10.1038/34775

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Particle physics:  Liberating quarks and gluons p330

Frank Wilczek

doi:10.1038/34778

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Neurobiology:  Phantoms of the brain p331

Jon H. Kaas

doi:10.1038/34782

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100 and 50 years ago p333

doi:10.1038/34785

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Crystallography:  Some are less equal than others p334

Alan Mackay

doi:10.1038/34787

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Genetic recombination:  From competition to collaboration p335

Roland Kanaar and Jan H. J. Hoeijmakers

doi:10.1038/34790

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Galaxy evolution:  Red giants in blue dwarfs p337

Stephen Battersby

doi:10.1038/34794

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Palaeoclimatology:  A glimpse of the glacial p338

Thomas F. Stocker

doi:10.1038/34797

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Alzheimer's disease:  A technical KO of amyloid- peptide p339

Christian Haass and Dennis J. Selkoe

doi:10.1038/34800

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Daedalus:  Crystalline clouds p340

David Jones

doi:10.1038/34804

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Art and Science

Dürer's diagnoses p341

The faces of the four apostles in Dürer's painting speak volumes about the saints' temperaments. This is no accident, as the artist was following the Renaissance medical theory of the four humours.

Martin Kemp

doi:10.1038/34806

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Scientific Correspondence

Embalming was used in Old Kingdom p343

Johann Koller, Ursula Baumer, Yoka Kaup, Hedwig Etspüler and Ulrich Weser

doi:10.1038/34809

First paragraph | Full Text | PDF (233K)

What can stochastic resonance do? p344

M. I. Dykman and P. V. E. McClintock

doi:10.1038/34812

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CCR5 is characteristic of Th1 lymphocytes p344

Pius Loetscher, Mariagrazia Uguccioni, Lorenza Bordoli, Marco Baggiolini, Bernhard Moser, Carlo Chizzolini and Jean-Michel Dayer

doi:10.1038/34814

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Straining the prion hypothesis p345

Christine F. Farquhar, Robert A. Somerville and Moira E. Bruce

doi:10.1038/34818

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Book Reviews

Instruments and the imagination p347

S. S. Schweber

doi:10.1038/34821

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Travels with a camera p347

doi:10.1038/34823

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Thinking machines p348

Igor Aleksander

doi:10.1038/34826

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Change of mind p349

Samuel H. Barondes

doi:10.1038/34833

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Hidden depths of underwater salvage p349

doi:10.1038/34835

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Worried to death? p350

John Galloway

doi:10.1038/34837

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Articles

Simulation of modern and glacial climates with a coupled global model of intermediate complexity p351

Andrey Ganopolski, Stefan Rahmstorf, Vladimir Petoukhov and Martin Claussen

doi:10.1038/34839

Abstract | Full Text | PDF (409K)

See also: News and Views by Stocker

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction p357

Andrei Glinka, Wei Wu, Hajo Delius, A. Paula Monaghan, Claudia Blumenstock and Christof Niehrs

doi:10.1038/34848

Abstract | Full Text | PDF (576K)

Letters to Nature

Evidence for a subsurface ocean on Europa p363

Michael H. Carr, Michael J. S. Belton, Clark R. Chapman, Merton E. Davies, Paul Geissler, Richard Greenberg, Alfred S. McEwen, Bruce R. Tufts, Ronald Greeley, Robert Sullivan, James W. Head, Robert T. Pappalardo, Kenneth P. Klaasen, Torrence V. Johnson, James Kaufman, David Senske, Jeffrey Moore, Gerhard Neukum, Gerald Schubert, Joseph A. Burns, Peter Thomas and Joseph Veverka

doi:10.1038/34857

First paragraph | Full Text | PDF (949K)

Geological evidence for solid-state convection in Europa's ice shell p365

R. T. Pappalardo, J. W. Head, R. Greeley, R. J. Sullivan, C. Pilcher, G. Schubert, W. B. Moore, M. H. Carr, J. M. Moore, M. J. S. Belton and D. L. Goldsby

doi:10.1038/34862

First paragraph | Full Text | PDF (378K)

Evidence for non-synchronous rotation of Europa p368

P. E. Geissler, R. Greenberg, G. Hoppa, P. Helfenstein, A. McEwen, R. Pappalardo, R. Tufts, M. Ockert-Bell, R. Sullivan, R. Greeley, M. J. S. Belton, T. Denk, B. Clark, J. Burns, J. Veverka and the Galileo Imaging Team

doi:10.1038/34869

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Episodic plate separation and fracture infill on the surface of Europa p371

Robert Sullivan, Ronald Greeley, Kim Homan, James Klemaszewski, Michael J. S. Belton, Michael H. Carr, Clark R. Chapman, Randy Tufts, James W. Head, III, Robert Pappalardo, Jeffrey Moore, Peter Thomas and the Galileo Imaging Team

doi:10.1038/34874

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Transport properties governed by surface barriers in Bi₂Sr₂CaCu₂O₈ p373

Dan T. Fuchs, Eli Zeldov, Michael Rappaport, Tsuyoshi Tamegai, Shuuichi Ooi and Hadas Shtrikman

doi:10.1038/34879

First paragraph | Full Text | PDF (626K)

Icosahedral packing of B₁₂ icosahedra in boron suboxide (B₆O) p376

Hervé Hubert, Bertrand Devouard, Laurence A. J. Garvie, Michael O'Keeffe, Peter R. Buseck, William T. Petuskey and Paul F. McMillan

doi:10.1038/34885

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See also: News and Views by Mackay

The timing of Pleistocene glaciations from a simple multiple-state climate model p378

Didier Paillard

doi:10.1038/34891

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Energy availability and habitat heterogeneity predict global riverine fish diversity p382

Jean-François Guégan, Sovan Lek and Thierry Oberdorff

doi:10.1038/34899

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Phantom sensations generated by thalamic microstimulation p385

Karen D. Davis, Zelma H. T. Kiss, Lei Luo, Ronald R. Tasker, Andres M. Lozano and Jonathan O. Dostrovsky

doi:10.1038/34905

First paragraph | Full Text | PDF (234K)

See also: News and Views by Kaas

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein p387

Bart De Strooper, Paul Saftig, Katleen Craessaerts, Hugo Vanderstichele, Gundula Guhde, Wim Annaert, Kurt Von Figura and Fred Van Leuven

doi:10.1038/34910

First paragraph | Full Text | PDF (382K)

See also: News and Views by Haass & Selkoe

NIP domain prevents N-type inactivation in voltage-gated potassium channels p390

Jochen Roeper, Sabine Sewing, Ying Zhang, Tobias Sommer, Siegmund G. Wanner and Olaf Pongs

doi:10.1038/34916

First paragraph | Full Text | PDF (325K)

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils p393

Jason P. Eiserich, Milena Hristova, Carroll E. Cross, A. Daniel Jones, Bruce A. Freeman, Barry Halliwell and Albert van der Vliet

doi:10.1038/34923

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes p397

Kathleen L. Collins, Benjamin K. Chen, Spyros A. Kalams, Bruce D. Walker and David Baltimore

doi:10.1038/34929

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Synergistic actions of Rad51 and Rad52 in recombination and DNA repair p401

Fiona E. Benson, Peter Baumann and Stephen C. West

doi:10.1038/34937

First paragraph | Full Text | PDF (264K)

See also: News and Views by Kanaar & Hoeijmakers

Stimulation by Rad52 of yeast Rad51- mediated recombination p404

Akira Shinohara and Tomoko Ogawa

doi:10.1038/34943

First paragraph | Full Text | PDF (355K)

See also: News and Views by Kanaar & Hoeijmakers

Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A p407

James H. New, Tomohiko Sugiyama, Elena Zaitseva and Stephen C. Kowalczykowski

doi:10.1038/34950

First paragraph | Full Text | PDF (331K)

See also: News and Views by Kanaar & Hoeijmakers

Crystal structure of p50/p65 heterodimer of transcription factor NF-B bound to DNA p410

Frances E. Chen, De-Bin Huang, Yong-Qing Chen and Gourisankar Ghosh

doi:10.1038/34956

First paragraph | Full Text | PDF (343K)

New on the Market

Products of science p415

Kicking off this eclectic collection is a new higher capacity 'smart' card — other items of interest include a microscope for birefringence imaging, an assortment of astronomy tools and a real-time LC/FTIR instrument.
compiled by Brendan Horton from information provided by the manufacturers. c b B H f i p b t

doi:10.1038/34962

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