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Nature 391, 231-232 (15 January 1998) | doi:10.1038/34542
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Structural biology: A mechanism for all polymerases
Thomas A. Steitz1
Possibly the earliest enzymatic activity to appear in evolution was that of the polynucleotide polymerases — the ability to replicate the genome accurately being a prerequisite for evolution itself. Thus, one might anticipate that the mechanism by which polymerases work would be both simple and universal.
- Thomas A. Steitz is in the Department of Molecular Biophysics and Biochemistry, and the Howard Hughes Medical Institute, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520-8114, USA.
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