Opinion

Trust and the bioethics industry p647

Radical developments in biology often appear to represent new conflicts with moral principles. Such perceptions are frequently misconceived, but independent consideration of ethical implications is beneficial.

doi:10.1038/39390

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Vaccines at risk p647

An imaginative attempt to tap Asian resources for the benefit of the developing world deserves more support.

doi:10.1038/39392

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News

French ministries in argument over release of asbestos report p649

Declan Butler

doi:10.1038/39394

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nature is organizing a half-day conference on: p649

doi:10.1038/39397

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US energy official departs with a 'get real' warning p650

Colin Macilwain

doi:10.1038/39399

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Transatlantic talks on space telescope p651

Tony Reichhardt

doi:10.1038/39402

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Political crisis threatens delay to revitalized Italian programme p651

Alison Abbott

doi:10.1038/39405

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Mentally disabled research subjects 'need protection' p652

Meredith Wadman

doi:10.1038/39407

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Row over alternative medicine's status at NIH p652

Meredith Wadman

doi:10.1038/39409

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'No need for haste' on Japan's fast reactor p653

Robert Triendl

doi:10.1038/39412

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World's biggest synchrotron open for business p653

Asako Saegusa

doi:10.1038/39414

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Islanders contest report on nuclear risks p654

Ehsan Masood

doi:10.1038/39417

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Brazil to sequence 'first plant pathogen' p654

Ricardo Bonalumé

doi:10.1038/39419

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Vaccine institute treads out a wary path p655

David Swinbanks

doi:10.1038/39421

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Council of Europe urged to ban human cloning p656

doi:10.1038/39424

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Briefings

Business booms for guides to biology's moral maze p658

The past decade has seen the rapid growth of bioethics as a focal point of public concern over new technologies. Nature's correspondents report on the ways in which the bioethics movement has developed around the world.

Meredith Wadman

doi:10.1038/39426

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Russia warned: act now or regret it later p659

Carl Levitin

doi:10.1038/39430

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Germany's past still casts a long shadow p660

Alison Abbott

doi:10.1038/39432

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France reaps benefits and costs of going by the book p661

Declan Butler

doi:10.1038/39435

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Japan's bioethics debate lags behind thinking in the West p661

Asako Saegusa

doi:10.1038/39439

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UK takes pride in 'principled pragmatism' p663

David Dickson

doi:10.1038/39442

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Policing ethical codes in India proves tough p663

K. S. Jayaraman

doi:10.1038/39444

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Correspondence

Pre-empting the arrival of a dark lord p665

Yuh Nung Jan

doi:10.1038/39446

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There are 'two cultures' p665

Friedrich Katscher

doi:10.1038/39448

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News and Views

Technology and the single electron p667

Marc Kastner

doi:10.1038/39450

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Developmental neurobiology:  Unscrambling a disabled brain p668

André M. Goffinet

doi:10.1038/39453

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Another matter:  Navel fluff p668

doi:10.1038/39456

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Genomic imprinting:  Making sense or antisense? p669

Wolf Reik and Miguel Constancia

doi:10.1038/39461

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100 and 50 years ago p669

doi:10.1038/39465

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Particle physics:  Panning for gold at the K stream p671

Frank Wilczek

doi:10.1038/39467

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G proteins:  The arginine finger strikes again p673

Henry R. Bourne

doi:10.1038/39470

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How converging fingers keep GTP in line p674

Henry R. Bourne

doi:10.1038/39472

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Ceramics:  Tough cookery p675

Derek Thompson

doi:10.1038/39475

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Alzheimer's disease:  The ins and outs of amyloid- p677

Konrad Beyreuther and Colin L. Masters

doi:10.1038/39479

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Geophysics:  A magnetic reversal record p678

Ronald T. Merrill

doi:10.1038/39482

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Evolutionary biology:  Insights from the echinoderms p679

Eric H. Davidson

doi:10.1038/39484

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Daedalus:  Seeing round corners p680

David Jones

doi:10.1038/39487

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Scientific Correspondence

Two sets of human-tropic pig retrovirus p681

Paul Le Tissier, Jonathan P. Stoye, Yasuhiro Takeuchi, Clive Patience and Robin A. Weiss

doi:10.1038/39489

First paragraph | Full Text | PDF (150K)

Rock-eating fungi p682

A. G. Jongmans, N. van Breemen, U. Lundström, P. A. W. van Hees, R. D. Finlay, M. Srinivasan, T. Unestam, R. Giesler, P.-A. Melkerud and M. Olsson

doi:10.1038/39493

First paragraph | Full Text | PDF (150K)

Sex in giant squid p683

Mark D. Norman and C. C. Lu

doi:10.1038/39497

First paragraph | Full Text | PDF (135K)

Homeotic transformation in Drosophila p684

B. Starling Emerald and J. K. Roy

doi:10.1038/39500

First paragraph | Full Text | PDF (104K)

Book Reviews

Betrayers of a global truth p685

Tim O'Riordan

doi:10.1038/39503

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Exploring Earth's mountains of fire p685

doi:10.1038/39505

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From cats to computers p686

Alastair I. M. Rae

doi:10.1038/39508

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Celebration of light and landscape p686

doi:10.1038/39510

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At a glance p687

Stephen Moorbath, Douglas Palmer and Thomas A. Moore

doi:10.1038/39513

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In retrospect chosen by Philippe Janvier p688

Philippe Janvier

doi:10.1038/39519

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Article

An intracellular protein that binds amyloid- peptide and mediates neurotoxicity in Alzheimer's disease p689

Shi Du Yan, Jin Fu, Claudio Soto, Xi Chen, Huaijie Zhu, Futwan Al-Mohanna, Kate Collison, Aiping Zhu, Eric Stern, Takaomi Saido, Masaya Tohyama, Satoshi Ogawa, Alex Roher and David Stern

doi:10.1038/39522

Abstract | Full Text | PDF (548K)

Letters to Nature

Detection of Geminga as a radio pulsar p697

V. M. Malofeev and O. I. Malov

doi:10.1038/39530

First paragraph | Full Text | PDF (309K)

A single-electron transistor made from a cadmium selenide nanocrystal p699

David L. Klein, Richard Roth, Andrew K. L. Lim, A. Paul Alivisatos and Paul L. McEuen

doi:10.1038/39535

First paragraph | Full Text | PDF (334K)

A tough SiAlON ceramic based on -Si₃N₄ with a whisker-like microstructure p701

I-Wei Chen and Anatoly Rosenflanz

doi:10.1038/39542

First paragraph | Full Text | PDF (367K)

Synthesis of microporous transition-metal-oxide molecular sieves by a supramolecular templating mechanism p704

Tao Sun and Jackie Y. Ying

doi:10.1038/39549

First paragraph | Full Text | PDF (264K)

A synthetic peptide ligase p706

Kay Severin, David H. Lee, Alan J. Kennan and M. Reza Ghadiri

doi:10.1038/39556

First paragraph | Full Text | PDF (318K)

Severe chemical ozone loss in the Arctic during the winter of 1995–96 p709

Rolf Müller, Paul J. Crutzen, Jens-Uwe Groo, Christoph Bürhl, James M. Russell, III, Hartwig Gernandt, Daniel S. McKenna and Adrian F. Tuck

doi:10.1038/39564

First paragraph | Full Text | PDF (382K)

The last two geomagnetic polarity reversals recorded in high-deposition-rate sediment drifts p712

J. E. T. Channell and B. Lehman

doi:10.1038/39570

First paragraph | Full Text | PDF (377K)

El Niño Southern Oscillation and tuna in the western Pacific p715

P. Lehodey, M. Bertignac, J. Hampton, A. Lewis and J. Picaut

doi:10.1038/39575

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Radical alterations in the roles of homeobox genes during echinoderm evolution p718

Christopher J. Lowe and Gregory A. Wray

doi:10.1038/39580

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Serrate2 is disrupted in the mouse limb-development mutant syndactylism p722

Arend Sidow, Monique S. Bulotsky, Anne W. Kerrebrock, Roderick T. Bronson, Mark J. Daly, Mary P. Reeve, Trevor L. Hawkins, Bruce W. Birren, Rudolf Jaenisch and Eric S. Lander

doi:10.1038/39587

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Severe neuropathies in mice with targeted mutations in the ErbB3 receptor p725

Dieter Riethmacher, Eva Sonnenberg-Riethmacher, Volker Brinkmann, Tomoichiro Yamaai, Gary R. Lewin and Carmen Birchmeier

doi:10.1038/39593

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Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice p730

Michael Sheldon, Dennis S. Rice, Gabriella D'Arcangelo, Hiroyuki Yoneshima, Kazunori Nakajima, Katsuhiko Mikoshiba, Brian W. Howell, Jonathan A. Cooper, Dan Goldowitz and Tom Curran

doi:10.1038/39601

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Neuronal position in the developing brain is regulated by mouse disabled-1 p733

Brian W. Howell, Richard Hawkes, Philippe Soriano and Jonathan A. Cooper

doi:10.1038/39607

First paragraph | Full Text | PDF (539K)

A CD4⁺T-cell subset inhibits antigen-specific T-cell responses and prevents colitis p737

Hervé Groux, Anne O'Garra, Mike Bigler, Matthieu Rouleau, Svetlana Antonenko, Jan E. de Vries and Maria Grazia Roncarolo

doi:10.1038/39614

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Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection p742

Robert S. Jack, Xiaolong Fan, Martin Bernheiden, Gabriele Rune, Monika Ehlers, Albert Weber, Gerhard Kirsch, Renate Mentel, Birgit Fürll, Marina Freudenberg, Gerd Schmitz, Felix Stelter and Christine Schütt

doi:10.1038/39622

First paragraph | Full Text | PDF (341K)

Imprinted expression of the Igf2r gene depends on an intronic CpG island p745

Anton Wutz, Oskar W. Smrzka, Norbert Schweifer, Karl Schellander, Erwin F. Wagner and Denise P. Barlow

doi:10.1038/39631

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Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses p749

Jianguo G. Gu and Amy B. MacDermott

doi:10.1038/39639

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Molecular basis of agonism and antagonism in the oestrogen receptor p753

Andrzej M. Brzozowski, Ashley C. W. Pike, Zbigniew Dauter, Roderick E. Hubbard, Tomas Bonn, Owe Engström, Lars Öhman, Geoffrey L. Greene, Jan-Åke Gustafsson and Mats Carlquist

doi:10.1038/39645

First paragraph | Full Text | PDF (625K)

Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue p758

Katrin Rittinger, Philip A. Walker, John F. Eccleston, Stephen J. Smerdon and Steven J. Gamblin

doi:10.1038/39651

First paragraph | Full Text | PDF (819K)

New on the Market

German fare leads off for Biotechnica p763

doi:10.1038/39658

Abstract | Full Text | PDF (293K)