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Scientific Correspondence
Nature 389, 681-682 (16 October 1997) | doi:10.1038/39489
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Junior Research Groups (W1 / W2)
- Cluster of Excellence "Multimodal Computing and Interaction"
- Saarbruecken Germany
PhD - Helmholtz International Graduate School for Infection Research
- Helmholtz-Zentrum fur Infektionsforschung
- Braunschweig Germany
Two sets of human-tropic pig retrovirus
Paul Le Tissier1, Jonathan P. Stoye1, Yasuhiro Takeuchi2, Clive Patience2 & Robin A. Weiss2
Abstract
Advances in controlling immunological rejection have raised the possibility that pigs could be used as a source of organs and tissues for transplantation into humans1,2. However, the report that one pig kidney cell line, PK15, produces Ctype retroviruses capable of infecting human cells3 has reinforced fears over the potential risks of viral infections associated with xenotransplantation4,5. Further support for these fears comes from the discovery of two different classes of porcine endogenous proviruses (PERVs), capable of infecting human cells, in PK15 cells as well as in a variety of normal porcine tissues.
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