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Nature 389, 674 (16 October 1997) | doi:10.1038/39472

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How converging fingers keep GTP in line

Henry R. Bourne1

The figure here shows a simplified view of how arginine fingers stabilize the GTPase-reaction transition state. Depicted are the GDP (grey), AlF4- (a red aluminium surrounded by four yellow fluorine atoms), the attacking water (grey) and the conserved glutamine residue (magenta) as seen in the GDP.

  1. Henry R. Bourne is in the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA.