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Nature 389, 669-671 (16 October 1997) | doi:10.1038/39461
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Genomic imprinting: Making sense or antisense?
Wolf Reik1 & Miguel Constancia1
Genomic imprinting is a genetic mechanism by which genes are expressed from the maternal or paternal chromosomes1, and loss of imprinting is involved in a variety of diseases and cancers. All the imprinted genes that have been studied so far have regions in which the maternal and paternal DNA copies are methylated differently at CpG residues — cytosine-guanine base pairs.
- Wolf Reik and Miguel Constancia are in the Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK.
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