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Nature 389, 334-335 (25 September 1997) | doi:10.1038/38614
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Assistant or Associate Professor - Cell & Systems Biology
- University of Toronto
- Toronto, ON Canada
John Innes Centre Project Leader in Plant or Microbial Sciences
- University of East Anglia
- Norwich, NR4 7TJ, UK
Inhibitory synapses: Anaesthetics set their sites on ion channels
The way in which volatile and gaseous general anaesthetics work has remained a puzzle ever since they were introduced into clinical practice during the 1840s. The prevailing view has been that anaesthetics (and, indeed, alcohol) do not have specific molecular targets in the conventional pharmacological sense, but that they nonspecifically disrupt nerve-membrane lipids1, 2.
- N. P. Franks and W. R. Lieb are in the Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, London SW7 2BZ, UK.
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