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Nature 389, 237-238 (18 September 1997) | doi:10.1038/38405

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Apoptosis:  Clues in the p53 murder mystery

Andrew Wyllie1

The paper by Polyak et al. on page 300 of this issue1 is a bold step towards understanding why expression of the oncosuppressor protein p53 leads to cell death. The issue is important because p53 forms part of a 'fast-track' connection between nuclear DNA damage and the complex but now relatively well-defined cellular apparatus that is responsible for death by apoptosis (Fig. 1

  1. Andrew Wyllie is in the Sir Alastair Currie CRC Laboratories, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.