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Nature 389, 122-123 (11 September 1997) | doi:10.1038/38116
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Tumour-suppressor genes: Killer in search of a motive?
Bruce Clurman1 & Mark Groudine1
The p53 gene has come to be known as a master guardian of the genome — by regulating the responses of cell growth and death to genotoxic stimuli, it protects vulnerable cells from malignant transformation (reviewed in refs 1 and 2). Consistent with this view, about half of all primary tumours contain mutant p53 alleles.
- Bruce Clurman and Mark Groudine are at the Fred Hutchinson Cancer Research Center, and the University of Washington School of Medicine, 1100 Fairview Avenue North, PO Box 19024, Seattle, Washington 98109-1024, USA.
e-mail: Email: bclurman@fhcrc.org.
e-mail: Email: markg@fhcrc.org
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