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Correspondence

Nature 389, 118 (11 September 1997) | doi:10.1038/38096

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Thalidomide is not a mutagen

John Ashby1

  1. Zeneca Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, UK

The possibility that the children of individuals affected by the teratogen thalidomide may inherit similar abnormalities has again been raised. Huang and McBride1 have presented data that purport to show that thalidomide is capable of binding covalently to the DNA of rat embryos whose mothers were treated with the chemical on day 12 of pregnancy.