Table of contents


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Opinion

Activism that is illegal and also ill judged p813

Campaigns aimed at environmental protection need to maintain a careful balance between conviction and fresh thinking. Industry and activists should aim for more of the latter.


Science loses in new ministry p813

Plans to merge Japan's Science and Technology Agency with the Ministry of Education need more thought.


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News

Radical restructuring in Japan merges science and education p815

Richard Nathan and Robert Triendl


New roles for science and technology council p815

Richard Nathan and Robert Triendl


Greenpeace defiant in face of threat from oil company p816

Ehsan Masood


Karolinska Institute disowns work of cancer researcher p816

Declan Butler


Dispute over insect resistance to crops p817

Meredith Wadman


Swiss research resting on its laurels p817

Quirin Schiermeier


Mir's problems could mean scale-down for science p818

Tony Reichhardt


State seeks independence in science policy p818

Peter Pockley


NAS president hints he may run again p819

Colin Macilwain


Cooperative Centres fight cuts proposal p819

Peter Pockley


News in Brief p820


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Correspondence

Peer review is a two-way process p822

Alistair Fielder, Hannah Vinyard and David Grant


Sacred circle p822

Roger Matthews


Space can't wait p823

Mary E. Musgrave and Richard Hopkin


Time and motion p823

Stuart Sherman


Identity crisis p823

J.-H. Klemme


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News and Views

Risk of sea-change in the Atlantic p825

Stefan Rahmstorf


Biological hydrostats:  Wrapping the armadillo's penis p826

Richard Wassersug


Quantum mechanics:  Atoms that agree to differ p827

D. Bouwmeester and A. Zeilinger


Genomic stability:  Silencing and DNA repair connect p829

Stephen P. Jackson


RNA structure:  A molecular contortionist p830

Jennifer A. Doudna


100 and 50 years ago p831


Autoimmune diabetes:  Retrovirus as trigger, precipitator or marker? p833

Christophe Benoist and Diane Mathis


Cryobiology:  Cold comfort for anglers and toxicologists p833

Tim Lincoln


Protein-protein interactions:  Calcium turns turquoise into gold p834

Tullio Pozzan


Daedalus:  A biased solid p835

David Jones


Obituary:  Hubert Horace Lamb (1913-97) p836

Mick Kelly


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Scientific Correspondence

Sources of the Maelstrom p837

B. Gjevik, H. Moe and A. Ommundsen


Morbillivirus in monk seal mass mortality p838

Albert Osterhaus, Jan Groen, Hubert Niesters, Marco van de Bildt, Byron Martina, Lies Vedder, Joseph Vos, Hans van Egmond, Ba Abou Sidi and Mohamed Ely Ould Barham


alpha-Synuclein in Lewy bodies p839

Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.-Y. Lee, John Q. Trojanowski, Ross Jakes and Michel Goedert


Endogenous proviruses as "mementos"? p840

Charles H. Langley and Brian Charlesworth


Reply:  Endogenous proviruses as "mementos"? p840

Jonathan Stoye


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Book Reviews

Transforming the theatre of surgery p841

Fred S. Rosen


Research remedies p842

Iain Smith


It's a frog's life p842


Everyman physics p842

Edwin L. Thomas


Oceans of truth p843

John Shepherd


Flights and fights p843

Paul Duffy


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Review

Design and synthesis of chromophores and polymers for electro-optic and photorefractive applications p845

Seth R. Marder, Bernard Kippelen, Alex K.-Y. Jen and Nasser Peyghambarian


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Letters to Nature

A direct image of the obscuring disk surrounding an active galactic nucleus p852

Jack F. Gallimore, Stefi A. Baum and Christopher P. O'Dea


Core formation on Mars and differentiated asteroids p854

Der-Chuen Lee and Alex N. Halliday


Effect of microgravity on the crystallization of a self-assembling layered material p857

Homayoun Ahari, Robert L. Bedard, Carol L. Bowes, Neil Coombs, Omer Dag, Tong Jiang, Geoffrey A. Ozin, Srebri Petrov, Igor Sokolov, Atul Verma, Gregory Vovk and David Young


Biodegradable block copolymers as injectable drug-delivery systems p860

Byeongmoon Jeong, You Han Bae, Doo Sung Lee and Sung Wan Kim


Influence of CO2 emission rates on the stability of the thermohaline circulation p862

Thomas F. Stocker and Andreas Schmittner


Critical behaviour and the evolution of fault strength during earthquake cycles p865

Moritz Heimpel


The Late Precambrian fossil Kimberella is a mollusc-like bilaterian organism p868

Mikhail A. Fedonkin and Benjamin M. Waggoner


A neuronal population code for sound localization p871

Douglas C. Fitzpatrick, Ranjan Batra, Terrence R. Stanford and Shigeyuki Kuwada


Loose-patch recordings of single quanta at individual hippocampal synapses p874

Lia Forti, Mario Bossi, Andrea Bergamaschi, Antonello Villa and Antonio Malgaroli


Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E p878

Steven W. Barger and Ashley D. Harmon


Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin p882

Atsushi Miyawaki, Juan Llopis, Roger Heim, J. Michael McCaffery, Joseph A. Adams, Mitsuhiko Ikura and Roger Y. Tsien


Kinetochores distinguish GTP from GDP forms of the microtubule lattice p888

Fedor F. Severin, Peter K. Sorger and Anthony A. Hyman


Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation p891

Richard K. Plemper, Sigrun Böhmler, Javier Bordallo, Thomas Sommer and Dieter H. Wolf


Marking of active genes on mitotic chromosomes p895

Emil F. Michelotti, Suzanne Sanford and David Levens


Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae p900

Yasumasa Tsukamoto, Jun-ichi Kato and Hideo Ikeda


Crystal structure of the breakage–reunion domain of DNA gyrase p903

Joo H. Morais Cabral, Andrew P. Jackson, Clare V. Smith, Nita Shikotra, Anthony Maxwell and Robert C. Liddington


Erratum: Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb p906

Concepción Rodriguez-Esteban, John W. R. Schwabe, Jennifer De La Peña, Bryon Foys, Brian Eshelman and Juan Carlos Izpisúa Belmonte


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New on the Market

DNA technology p907

This round-up of molecular tools includes a thermal printer module, a PCR-product amplification detection system, plasmid purification kits, and a system for in situ hybridization, RT-PCR, PRINS and immunohistochemistry.

compiled by Brendan Horton from information provided by the manufacturers.


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