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Nature 388, 427-428 (31 July 1997) |

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Neurobiology:  Long-distance long-term depression

Roger A. Nicoll1 & Robert C. Malenka1

Those who study learning and memory generally agree that many forms of these processes are due to long-lasting, use-dependent changes in the strength of synapses in the brain. Depending on the pattern of synaptic activation, synapses can show either a long-term potentiation (LTP) or a long-term depression (LTD).

  1. Roger A. Nicoll is in the Departments of Cellular and Molecular Pharmacology, and Physiology, University of California, San Francisco, California 94143, USA.
  2. Robert C. Malenka is in the Departments of Psychiatry and Physiology, University of California, San Francisco, California 94143, USA.