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Nature 388, 232-233 (17 July 1997) |

Familial Parkinson's disease:  The awakening of alpha-synuclein

Michel Goedert1

Parkinson's disease is characterized by a progressive neuronal degeneration which predominantly affects the dopaminergic nerve cells of the substantia nigra in the brain; the surviving cells contain characteristic cytoplasmic inclusions known as Lewy bodies, which are not normally present. Like many neurodegenerative disorders, Parkinson's disease either occurs in a common sporadic form or it can be inherited in a much rarer, familial form.

  1. Michel Goedert is at the Medical Research Council Laboratory of Molecular Biology, Hills Road, CambridgeCB2 2QH, UK.