Table of contents


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Opinion

Two cheers for the multilateral malaria initiative p211

A major health crisis is being belatedly addressed by those who can make a difference. Real progress can be anticipated — provided participants act with regard for each others' constraints and experience.


Martian life to be avoided p211

Sending people to Mars is a bad idea.


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News

Asian economies lead increase in carbon dioxide emissions p213

Ehsan Masood


Technology programme thinks small p213

Colin Macilwain


NASA seeks 'fair exchange' of technical data p214

Tony Reichhardt


Canada wins biotech boost of cancer vaccine project p214

David Spurgeon


US funds for ITER safe for one more year p214

Colin Macilwain


Mars rover meets rock with complex past p215

Stephen Battersby


NASA 'must fill gaps' to finalize streamlined plans for human expedition p215

Tony Reichhardt


Japan's life sciences take integrated road p216

Robert Triendl and David Swinbanks


Clinton backs Congressional efforts on genetic discrimination p216

Sally Lehrman


'USA should fund half transatlantic links' p217

Alison Abbott and Colin Macilwain


Encryption technology divides policy-makers p217


NIH urged to address chimp care 'crisis' p218

Colin Macilwain


Small increase planned in German budget p218

Alison Abbott


Malaria meeting charts rocky path ahead p219

Declan Butler


US government forbids export of equipment to Indian nuclear centres p220


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Correspondence

Limit the number of grants per person p222

Frederick Sachs


True to Tony Blair p222

Anne Campbell, (Member of Parliament for Cambridge)


Getting ahead of one's self p222

Giorgio G. C. Palumbo


Capital Letters p222

G. P. Findlay


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Commentary

Need for change in Japan's universities p223

Japan's universities need strong leadership to give young scientists, foreign staff and women the opportunities that are denied them. Academics should have more of a sense of crisis over what is an unacceptable situation.


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News and Views

A molecular handle on the Neanderthals p225

The sequencing of mitochondrial DNA from Neanderthal fossil bone is a terrific achievement. Among the conclusions to be drawn from the data is that there was a period of more than 500,000 years during which Neanderthals and the line leading to modern humans evolved independently.

Ryk Ward and Chris Stringer


Volcanology:  The giant Popocatépetl stirs p227

Servando De la Cruz-Reyna and Claus Siebe


Spongiform encephalopathies:  Tracking turncoat prion proteins p228

Colin L. Masters and Konrad Beyreuther


Symbiosis:  Making light work of adaptation p229

Robert W. Buddemeier


Immunodeficiency viruses:  Spoilt for choice of co-receptors p230

Paul R. Clapham and Robin A. Weiss


100 and 50 years ago p232


Asteroids:  Made of craters p232

Stephen Battersby


Familial Parkinson's disease:  The awakening of alpha-synuclein p232

Michel Goedert


Daedalus:  Guided lightning p233

David Jones


Obituary:  Dorothy Hill (1907-97) p234

Peter A. Jell


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Scientific Correspondence

Fatigue, alcohol and performance impairment p235

Drew Dawson and Kathryn Reid


Entropy difference between crystal phases p235

P. G. Bolhuis, D. Frenkel, Siun-Choun Mau and David A. Huse


Reply:  Entropy difference between crystal phases p236

L. V. Woodcock


Metallothionein in snail Cd and Cu metabolism p237

Reinhard Dallinger, Burkhard Berger, Peter Hunziger and Jeremias H. R. Kgi


A new SIV co-receptor, STRL33 p238

Ghalib Alkhatib, Fang Liao, Edward A. Berger, Joshua M. Farber and Keith W. C. Peden


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Book Reviews

Tales of memory and imagination p239

Stuart Sutherland reviews Hystories: Hysterical Epidemics and Modern Culture by Elaine Showalter and Junk Psychology: Fallacies in Studies of 'Repression' and Childhood Trauma by Harrison G. Pope,, Jr


Inside knowledge p240

Andrew Whiten reviews Interpreting Minds: The Evolution of a Practice by Radu Bogdan


Picnic in the park p240


Ways of seeing p240

John M. Kennedy reviews Art and Representation: New Principles in the Analysis of Pictures by John Willats


Metallurgy — and other animals p242

Paul Calvert reviews Stuff: The Materials the World is Made of by Ivan Amato


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Article

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade p243

Susan Tsunoda, Jimena Sierralta, Yumei Sun, Ruth Bodner, Emiko Suzuki, Ann Becker, Michael Socolich and Charles S. Zuker


Top

Letters to Nature

A high deuterium abundance at redshift z = 0.7 p250

J. K. Webb, R. F. Carswell, K. M. Lanzetta, R. Ferlet, M. Lemoine, A. Vidal-Madjar and D. V. Bowen


Chaotic dynamics of falling disks p252

Stuart B. Field, M. Klaus, M. G. Moore and Franco Nori


Conductivity enhancement in single-walled carbon nanotube bundles doped with K and Br p255

R. S. Lee, H. J. Kim, J. E. Fischer, A. Thess and R. E. Smalley


Evidence for charge transfer in doped carbon nanotube bundles from Raman scattering p257

A. M. Rao, P. C. Eklund, Shunji Bandow, A. Thess and R. E. Smalley


Seismological evidence for three-dimensional melt migration beneath the East Pacific Rise p259

Robert A. Dunn and Douglas R. Toomey


Nearly synchronous climate change in the Northern Hemisphere during the last glacial termination p263

Larry Benson, James Burdett, Steve Lund, Michaele Kashgarian and Scott Mensing


Landscape ecology of algal symbionts creates variation in episodes of coral bleaching p265

Rob Rowan, Nancy Knowlton, Andrew Baker and Javier Jara


A polymorphism maintained by opposite patterns of parasitism and predation p269

John E. Losey, Jason Harmon, Ford Ballantyne and Carrie Brown


Multistability of cognitive maps in the hippocampus of old rats p272

Carol A. Barnes, Matthew S. Suster, Jiemin Shen and Bruce L. McNaughton


cAMP-induced switching in turning direction of nerve growth cones p275

Hong-jun Song, Guo-li Ming and Mu-ming Poo


Synapse specificity of long-term potentiation breaks down at short distances p279

Florian Engert and Tobias Bonhoeffer


Molecular assessment of the potential transmissibilities of BSE and scrapie to humans p285

Gregory J. Raymond, James Hope, David A. Kocisko, Suzette A. Priola, Lynne D. Raymond, Alex Bossers, James Ironside, Robert G. Will, Shu G. Chen, Robert B. Petersen, Pierluigi Gambetti, Richard Rubenstein, Mari A. Smits, Peter T. Lansbury, Jr and Byron Caughey


A minK–HERG complex regulates the cardiac potassium current IKr p289

Thomas V. McDonald, Zhihui Yu, Zhen Ming, Eugen Palma, Marian B. Meyers, Ke-Wei Wang, Steve A. N. Goldstein and Glenn I. Fishman


P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1 p292

J. Alexandra Rowe, Joann M. Moulds, Christopher I. Newbold and Louis H. Miller


Expression cloning of new receptors used by simian and human immunodeficiency viruses p296

HongKui Deng, Derya Unutmaz, Vineet N. KewalRamani and Dan R. Littman


X-linked IAP is a direct inhibitor of cell-death proteases p300

Quinn L. Deveraux, Ryosuke Takahashi, Guy S. Salvesen and John C. Reed


Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic p304

Jaeseob Kim, Kirby Johnson, Hui Ju Chen, Sean Carroll and Allen Laughon


erratum:  Differential activation of transcription factors induced by Ca2+ response amplitude and duration p308

Ricardo E. Dolmetsch, Richard S. Lewis, Christopher C. Goodnow and James I. Healy


erratum:  Large-scale tectonic deformation inferred from small earthquakes p308

Falk Amelung and Geoffrey King


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