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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Nature volume 386, pages 804–810 (1997)Cite this article

Abstract

Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DMA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2.

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Author information

Author notes

  1. Dae-Sik Lim

    Present address: Department of Pediatric Oncology, Johns Hopkins Hospital, 720 Rutland Av. Ross 345, Baltimore, Maryland, 21205, USA

Authors and Affiliations

  1. Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    Shyam K. Sharan, Christopher Dinh & Allan Bradley

  2. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    Shyam K. Sharan, Eva Regel, Christopher Dinh & Allan Bradley

  3. Department of Biochemistry, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    Urs Albrecht & Gregor Eichele

  4. Lexicon Genetics Inc., 4000 Research Forest Drive, The Woodlands, Texas, 77381, USA

    Masami Morimatsu, Dae-Sik Lim, Arthur Sands & Paul Hasty

  5. Department of Molecular Genetics, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

    Masami Morimatsu

  6. Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060, Japan

    Masami Morimatsu

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Sharan, S., Morimatsu, M., Albrecht, U. et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386, 804–810 (1997). https://doi.org/10.1038/386804a0

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