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Letters to Nature

Nature 384, 467-470 (5 December 1996) | doi:10.1038/384467a0; Accepted 21 October 1996

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

Paul T. Kotzbauer*, Patricia A. Lampe†, Robert O. Heuckeroth‡, Judith P. Golden†, Douglas J. Creedon†, Eugene M. Johnson Jr† & Jeffrey Milbrandt*

  1. *,  Division of Laboratory Medicine, Department of Pathology and Department of Internal Medicine, and †,  Department of Neurology and Department of Molecular Biology and Pharmacology, and ‡ Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, Missouri 63110, USA
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THE normal development of the vertebrate nervous system entails the death of 30–70% of the neurons originally generated in most neuronal populations1. This naturally occurring cell death is regulated by specific neurotrophic factors that promote neuronal survival and which are produced in limiting quantities by target cells, glial cells and neurons. These factors are also of potential utility as therapeutic agents for neurodegenerative diseases2. Here we describe the purification and cloning of a new neurotrophic factor, identified on the basis of its ability to support the survival of sympathetic neurons in culture. This factor, neurturin, is structurally related to glial-cell-line-derived neurotrophic factor (GDNF) 3. These factors can each activate the MAP kinase signalling pathway in cultured sympathetic neurons and support the survival of sympathetic neurons, as well as of sensory neurons of the nodose and dorsal root ganglia. Thus, neurturin and GDNF together now define a new family of neurotrophic factors.