| | Opinion |  |
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| | Keep an eye on genetic screening 93
The potential abuses of genetic screening should not be exaggerated, but neither should they be ignored. Governments must ensure that private screening services operate responsibly. Careful oversight, even in a climate of deregulation, is essential.
doi:10.1038/384093a0
PDF (257K)
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| | Eurovision for science? 93
A newly conceived association for science and society in Europe deserves antenatal support.
doi:10.1038/384093b0
PDF (257K)
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| | News | |
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| | Acceptance of marijuana therapy prompts call for more research 95
Sally Lehrman
doi:10.1038/384095a0
PDF (230K)
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| | Car-maker turns to cannabis — for fibre 95
doi:10.1038/384095b0
PDF (230K)
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| | CERN seeks bank loans to construct LHC 96
Alison Abbott
doi:10.1038/384096a0
PDF (252K)
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| | Japan's tokamak success boosts its bid for reactor 96
David Swinbanks
doi:10.1038/384096b0
PDF (252K)
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| | Election outcome signals few policy shifts 97
Colin Macilwain
doi:10.1038/384097a0
PDF (278K)
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| | Affirmative action curb 'will hit minority recruitment' 97
Sally Lehrman
doi:10.1038/384097b0
PDF (278K)
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| | Space agency reform plans under scrutiny 98
Declan Butler
doi:10.1038/384098a0
PDF (390K)
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| | Bids open for supercomputing centres 98
Colin Macilwain
doi:10.1038/384098b0
PDF (390K)
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| | Scaled-down Cluster mission aims for relaunch in 1999 99
Alison Abbott
doi:10.1038/384099a0
PDF (286K)
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| | Rocket failure leads to grounding of small US satellites 99
Tony Reichhardt
doi:10.1038/384099b0
PDF (286K)
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| | Prediction sceptics 'must tackle bias' in earthquake research 100
Ehsan Masood
doi:10.1038/384100a0
PDF (374K)
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| | Roche claims victory in bid for European Taq patent 100
David Dickson
doi:10.1038/384100b0
PDF (374K)
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| | India commissions its thorium reactor 100
K. S. Jayaraman
doi:10.1038/384100c0
PDF (374K)
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| | FDA resists regulatory role in gene tests 101
Meredith Wadman
doi:10.1038/384101a0
PDF (278K)
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| | News in Brief | |
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| | Nerws in brief 102
doi:10.1038/384102a0
PDF (276K)
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| | Correspondence | |
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| | Axe the army of cheap labour 103
Srin Sastry
doi:10.1038/384103a0
PDF (288K)
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| | Axe the army of cheap labour 103
Christopher Miller
doi:10.1038/384103b0
PDF (288K)
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| | Axe the army of cheap labour 103
Gerard Vassiliou
doi:10.1038/384103c0
PDF (288K)
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| | Back to the roots 103
David G. Morris
doi:10.1038/384103d0
PDF (288K)
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| | Collaboration still the key to Rosetta 104
R. M. Bonnet
doi:10.1038/384104a0
PDF (497K)
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| | Female forum 104
Seth Isenberg
doi:10.1038/384104b0
PDF (965K)
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| | Back to nature 105
Mark Cantley
doi:10.1038/384105a0
PDF (485K)
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| | Making waves 105
Ernst Mayer
doi:10.1038/384105b0
PDF (485K)
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| | Stop knocking social sciences 106
David Edge
doi:10.1038/384106a0
References | PDF (284K)
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| | Abstract values 106
Neville W. Goodman
doi:10.1038/384106b0
References | PDF (284K)
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| | No miracle 106
Pushpa M. Bhargava
doi:10.1038/384106c0
PDF (284K)
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| | Spanish practice 106
Luis M. Corrochano
doi:10.1038/384106d0
PDF (284K)
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| | Commentary |  |
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| | On the likelihood of habitable worlds 107
The anthropic principle has gained much popularity among cosmologists. But, faced with a need for historical explanation, biologists are bound to find it a cop-out.
John Maynard Smith & Eörs Szathmáry
doi:10.1038/384107a0
References | PDF (275K)
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| | ANNOUNCEMENT | |
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| | A new opportunity for science in Europe 108
Closer integration between European research and the needs of society would have a positive effect on the development of Europe while helping to shape the future of its scientific communities. To promote those aims we intend to create 'Euroscience', an open association of all those interested in science and its consequences on society.
Françoise Praderie
doi:10.1038/384108a0
PDF (294K)
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| | News and Views |  |
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| | Pictures of MHC restriction 109
This year's Nobel prize in physiology or medicine was awarded for the discovery, in 1974, of a fundamental principle in immunology. The underlying interactions are now being seen in three dimensions.
Peter Parham
doi:10.1038/384109a0
References | PDF (629K)
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| | A nanotube molecular tool 111
David Keller
doi:10.1038/384111a0
References | PDF (293K)
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| | Computing with cyclic AMP 113
Eve Marder
doi:10.1038/384113a0
References | PDF (586K)
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| | Pulling the knot tight 114
H. K. Moffatt
doi:10.1038/384114a0
References | PDF (288K)
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| | Brain waves deciphered 115
John P. Miller
doi:10.1038/384115a0
References | PDF (578K)
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| | Fossil fortune cookie 115
Henry Gee
doi:10.1038/384115b0
PDF (257K)
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| | One on one meets two 117
Simon Wain-Hobson
doi:10.1038/384117a0
References | PDF (619K)
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| | Harmonics to quicken the pulse 118
Paul Corkum
doi:10.1038/384118a0
References | PDF (558K)
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| | Patching up Hedgehog 119
Roel Nusse
doi:10.1038/384119a0
References | PDF (549K)
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| | Algal transport 120
David Jones
doi:10.1038/384120a0
PDF (289K)
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| | Scientific Correspondence | |
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| | Kinematics of phalarope spinning 121
Bryan S. Obst, William M. Hamner, Peggy P. Hamner, Eric Wolanski, Margaret Rubega & Bates Littlehales
doi:10.1038/384121a0
References | PDF (240K)
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| | Electrophoretic mobility of DNA knots 122
Andrzej Stasiak, Vsevolod Katritch, Jan Bednar, Didier Michoud & Jacques Dubochet
doi:10.1038/384122a0
References | PDF (252K)
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| | Origin of patterning in neural tubes 123
Hiroshi Wada, Peter W. H. Holland & Noriyuki Satoh
doi:10.1038/384123a0
References | PDF (297K)
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| | Neuronal cell death and tPA 123
Stella E. Tsirka, Andrew D. Rogove & Sidney Strickland
doi:10.1038/384123b0
References | PDF (601K)
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| | 124
doi:10.1038/384124a0
PDF (322K)
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| | Book Reviews | |
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| | The Darwinian family 125
Howard Gardner reviews Born to Rebel: Birth Order, Family Dynamics and Creative Lives
By
Frank J. Sulloway
doi:10.1038/384125a0
PDF (135K)
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| | Of serpents, sharks and shells 126
Olivia Judson reviews Sixty Years of Biology: Essays on Evolution and Development
By
John Tyler Bon-ner, Edward O. Wilson & Geerat Vermeij
doi:10.1038/384126a0
PDF (586K)
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| | Object lessons in vision 127
Anya Hurlbert reviews High-level Vision: Object Recognition and Visual Cognition
By
Shimon Ullman
doi:10.1038/384127a0
PDF (270K)
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| | Mum's a test-tube 127
Benno Müller-Hill reviews Quest for Perfection: The Drive to Breed Better Human Beings
By
Gina Maranto
doi:10.1038/384127b0
PDF (894K)
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| | Textbooks at a glance 128
Stars as Laboratories for Fundamental Physics
By
Georg G. Raffelt, George , Robert L. , Catherine BackusParkerConstable & Peter Doyle
doi:10.1038/384128a0
PDF (641K)
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| | Articles |  |
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| | The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog 129
Donna M. Stone, Mary Hynes, Mark Armanini, Todd A. Swanson, Qimin Gu, Ronald L. Johnson, Matthew P. Scott, Diane Pennica, Audrey Goddard, Heidi Phillips, Markus Noll, Joan E. Hooper, Frederic de Sauvage & Arnon Rosenthal
doi:10.1038/384129a0
Abstract & References | PDF (1,356K)
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| | Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 134
David N. Garboczi, Partho Ghosh, Ursula Utz, Qing R. Fan, William E. Biddison & Don C. Wiley
doi:10.1038/384134a0
Abstract & References | PDF (2,042K)
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| | Letters | |
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| | Geometry and physics of knots 142
Vsevolod Katritch, Jan Bednar, Didier Michoud, Robert G. Scharein, Jacques Dubochet & Andrzej Stasiak
doi:10.1038/384142a0
First paragraph & References | PDF (905K)
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| | Dislocation-mediated melting of a two-dimensional crystal 145
L. Pauchard, D. Bonn & J. Meunier
doi:10.1038/384145a0
First paragraph & References | PDF (823K)
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| | Nanotubes as nanoprobes in scanning probe microscopy 147
Hongjie Dai, Jason H. Hafner, Andrew G. Rinzler, Daniel T. Colbert & Richard E. Smalley
doi:10.1038/384147a0
First paragraph & References | PDF (1,010K)
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| | Self-replicating amphiphilic monolayers 150
Rivka Maoz, Sophie Matlis, Elaine DiMasi, Benjamin M. Ocko & Jacob Sagiv
doi:10.1038/384150a0
First paragraph & References | PDF (973K)
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| | Effect of slab temperature on deep-earthquake aftershock productivity and magnitude–frequency relations 153
Douglas A. Wiens & Hersh J. Gilbert
doi:10.1038/384153a0
First paragraph & References | PDF (864K)
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| | A Pikaia-like chordate from the Lower Cambrian of China 157
D.-G. Shu, S. Conway Morris & X.-L. Zhang
doi:10.1038/384157a0
First paragraph & References | PDF (621K)
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| | A new brain region for coordinating speech articulation 159
Nina F. Dronkers
doi:10.1038/384159a0
First paragraph & References | PDF (1,289K)
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| | Odour encoding by temporal sequences of firing in oscillating neural assemblies 162
Michael Wehr & Gilles Laurent
doi:10.1038/384162a0
First paragraph & References | PDF (1,222K)
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| | Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuit 166
Chris M. Hempel, Pierre Vincent, Stephen R. Adams, Roger Y. Tsien & Allen I. Selverston
doi:10.1038/384166a0
First paragraph & References | PDF (1,092K)
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| | Timing of neurotransmission at fast synapses in the mammalian brain 170
Bernardo L. Sabatini & Wade G. Regehr
doi:10.1038/384170a0
First paragraph & References | PDF (647K)
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| | Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis 173
K. Michael Weidner, Silvana Di Cesare, Martin Sachs, Volker Brinkmann, Jürgen Behrens & Walter Birchmeier
doi:10.1038/384173a0
First paragraph & References | PDF (1,625K)
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| | Biochemical evidence that Patched is the Hedgehog receptor 176
Valeria Marigo, Robert A. Davey, Yi Zuo, James M. Cunningham & Clifford J. Tabin
doi:10.1038/384176a0
First paragraph & References | PDF (971K)
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| | CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5 179
Lijun Wu, Norma P. Gerard, Richard Wyatt, Hyeryun Choe, Cristina Parolin, Nancy Ruffing, Alessândra Borsetti, Angelo A. Cardoso, Elizabeth Desjardin, Walter Newman, Craig Gerard & Joseph Sodroski
doi:10.1038/384179a0
First paragraph & References | PDF (1,142K)
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| | CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5 184
Alexandra Trkola, Tatjana Dragic, James Arthos, James M. Binley, William C. Olson, Graham P. Allaway, Cecilia Cheng-Mayer, James Robinson, Paul J. Maddon & John P. Moore
doi:10.1038/384184a0
First paragraph & References | PDF (867K)
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| | Crystal structure of a T-cell receptor  -chain complexed with a superantigen 188
Barry A. Fields, Emilio L. Malchiodi, Hongmin Li, Xavier Ysern, Cynthia V. Stauffacher, Patrick M. Schlievert, Klaus Karjalainen & Roy A. Mariuzza
doi:10.1038/384188a0
First paragraph & References | PDF (1,407K)
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| | Product Review | |
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| | Natural choices for the neurosciences 193
Various new systems and reagents for neuroscientific study are featured this week, including a new drug delivery system for therapeutic agents, a receptor available for drug screening programmes and a vibrating ion probe system.
Brendan Horton
doi:10.1038/384193a0
PDF (1,085K)
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