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Letters to Nature
Nature 384, 72 - 74 (07 November 1996); doi:10.1038/384072a0

wingless refines its own expression domain on the Drosophila wing margin

Eric J. Rulifson*, Craig A. Micchelli*, Jeffrey D. Axelrod§, Norbert Perrimon & Seth S. Blair

*Program for Neuroscience and Department of Zoology, University of Wisconsin, 250 N. Mills Street, Madison, Wisconsin 53706, USA
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
§Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA

THE imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compart-ments1. However, in most cases precise boundaries are formed between different cell types without early compartmentalization2. One such boundary occurs between the wingless (wg)-expressing cells of the wing margin and the adjacent proneural cells, which give rise to margin sensory bristles. Here we show that this boundary arises in part by a mechanism of 'self-refinement', by which wingless protein (Wg) represses wg expression in adjacent cells. Cells unable to receive the Wg signal do not resolve the boundary between H>g-expressing and proneural cells.

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