Nature Publishing Group, publisher of Nature, and other science journals and reference works
Nature
my account e-alerts subscribe register
   
Friday 21 July 2017
Journal Home
Current Issue
AOP
Archive
Download PDF
References
Export citation
Export references
Send to a friend
More articles like this

Article
Nature 382, 685 - 691 (22 August 1996); doi:10.1038/382685a0

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Shi Du Yan, Xi Chen, Jin Fu, Ming Chen, Huaijie Zhu, Alex Roher*, Timothy Slattery, Lei Zhao, Mariko Nagashima, John Morser, Antonio Migheli, Peter Nawroth§, David Stern & Ann Marie Schmidt

Departments of Pathology, Surgery, Medicine and Physiology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032, USA * Sun Health Research Institute, 10515 Santa Fe Drive, Sun City, Arizona 85372, USA Berlex Biosciences, San Pablo Avenue, Richmond, California 94804, USA Clinica Neurologica II, University of Torino, 10126 Torino, Italy § Department of Medicine, University of Heidelberg, Bergheimen Str. 58, 69115 Heidelberg, Germany

Amyloid-beta peptide is central to the pathology of Alzheimer's disease, because it is neurotoxic—directly by inducing oxidant stress, and indirectly by activating microglia. A specific cell-surface acceptor site that could focus its effects on target cells has been postulated but not identified. Here we present evidence that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia. Increased expression of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death.

------------------

References

1. Goedert, M. Trends Neurosci. 16, 460−465 (1993). | Article | PubMed | ISI | ChemPort |
2. Haass, C. & Selkoe, D. Cell 7, 1039−1042 (1994).
3. Kosik, K. J. Cell. Biol. 127, 1501−1504 (1994). | Article | PubMed | ISI | ChemPort |
4. Trojanowski, J. & Lee, V. Am. J. Pathol. 144, 449−453 (1994). | PubMed | ISI | ChemPort |
5. Koo, E., Park, L. & Selkoe, D. Proc. Natl Acad. Sci. USA 90, 4748−4752 (1993). | PubMed | ChemPort |
6. Yanker, B., Duffy, L. & Kirschner, D. Science 250, 279−282 (1990). | PubMed | ISI | ChemPort |
7. Davis, J., McMurray, H. & Schubert, D. Biochem. Biophys. Res. Commun. 189, 1096−1100 (1992). | Article | PubMed | ChemPort |
8. Pike, C. et al. Neuroscience 13, 1676−1687 (1993). | PubMed | ChemPort |
9. Hensley, K. et al. Proc. Natl Acad. Sci. USA 91, 3270−3274 (1994). | PubMed | ChemPort |
10. Behl, C., Davis, J., Lesley, R. & Schubert, D. Cell 77, 817−827 (1994). | Article | PubMed | ISI | ChemPort |
11. Meda, L. et al. Nature 374, 647−650 (1995). | Article | PubMed | ISI | ChemPort |
12. Klegeris, A., Walker, D. & McGeer, P. Biochem. Biophys. Res. Commun. 199, 984−991 (1994). | Article | PubMed | ChemPort |
13. Araujo, D. & Cotman, C. Brain Res. 569, 141−145 (1992). | Article | PubMed | ChemPort |
14. Joslin, G. et al. J. Biol. Chem. 266, 21897−21902 (1991). | PubMed | ChemPort |
15. Fraser, P. et al. J. Neurochem. 61, 298−305 (1993). | PubMed | ISI | ChemPort |
16. Ghiso, J. et al. Biochem. J. 293, 27−30 (1993). | PubMed | ISI | ChemPort |
17. Kimura, H. & Schubert, D. Proc. Natl Acad. Sci. USA 90, 7508−7512 (1993). | PubMed | ChemPort |
18. Strittmatter, W. et al. Proc. Natl Acad. Sci. USA 90, 1977−1981 (1993). | PubMed | ChemPort |
19. Strittmatter, W. et al. Exp. Neurol. 122, 327−334 (1993). | Article | PubMed | ChemPort |
20. Schwarzman, A. Proc. Natl Acad. Sci. USA 91, 8368−8372 (1994). | PubMed | ChemPort |
21. Kisilevsky, R. et al. Nature Med. 1, 143−148 (1995). | Article | PubMed | ISI | ChemPort |
22. Schmidt, A-M. et al. J. Biol. Chem. 267, 14987−14997 (1992). | PubMed | ISI | ChemPort |
23. Neeper, M. et al. J. Biol. Chem. 267, 14998−15004 (1992). | PubMed | ISI | ChemPort |
24. Hori, O. et al. J. Biol. Chem. 270, 25752−25761 (1995). | Article | PubMed | ISI | ChemPort |
25. Rauvala, H. & Pihlaskari, R. J. Biol. Chem. 262, 16625−16635 (1987). | PubMed | ChemPort |
26. Yan, S-D. et al. Proc. Natl Acad. Sci. USA 91, 7787−7791 (1994). | PubMed | ChemPort |
27. Yan, S-D. et al. Nature Med. 1, 693−699 (1995). | Article | PubMed | ISI | ChemPort |
28. Harris, J. et al. Exp. Neurol. 131, 193−202 (1995). | Article | PubMed | ISI | ChemPort |
29. Mattson, M. & Goodman, Y. Brain Res. 676, 219−224 (1995). | Article | PubMed | ISI | ChemPort |
30. Thomas, T. et al. Nature 380, 168−171 (1996). | Article | PubMed | ISI | ChemPort |
31. Osborn, L. et al. Cell 59, 1203−1211 (1989). | Article | PubMed | ISI | ChemPort |
32. Roher, A. et al. J. Biol. Chem. 268, 3072−3083 (1993). | PubMed | ISI | ChemPort |
33. Schmidt, A-M. et al. J. Clin. Invest. 91, 2155−2168 (1993). | PubMed | ISI | ChemPort |
34. Bocchini, V. et al. J. Neurosci. Res. 31, 616−621 (1992). | Article | PubMed | ISI | ChemPort |
35. Dickson, D. et al. Glia 7, 75−83 (1993). | Article | PubMed | ISI | ChemPort |
36. McGeer, P. et al. Glia 7, 84−92 (1993). | Article | PubMed | ChemPort |
37. Wautier, J-L. et al. J. Clin. Invest. 97, 238−243 (1996). | PubMed | ISI | ChemPort |
38. Schmidt, A-M. et al. J. Clin. Invest. 96, 1395−1403 (1995). | PubMed | ISI | ChemPort |
39. Yan et al. J. Biol. Chem. 269, 9889−9897 (1994). | PubMed | ISI | ChemPort |
40. Rogers, J. et al. Neurology 43, 1609−1611 (1993). | PubMed | ISI | ChemPort |
41. Breitner, J. et al. Neurology 44, 227−232 (1994). | PubMed | ChemPort |
42. Gumkowski, F. et al. Blood Vessels 24, 11−18 (1987). | PubMed | ISI | ChemPort |
43. Yavin, E. & Yavin, Z. J. Cell Biol. 62, 540−546 (1974). | Article | PubMed | ISI | ChemPort |
44. Dennery, P., Kramer, C. & Alpert, S. Am. J. Respir. Cell Mol. Biol. 3, 137−144 (1990). | PubMed | ChemPort |
45. Brett, J. et al. Am. J. Pathol. 143, 1699−1712 (1993). | PubMed | ISI | ChemPort |



© 1996 Nature Publishing Group
Privacy Policy