| | Opinion |  |
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| | AIDS myths that need eradicating 283
As emerged vividly at this year's international AIDS conference, prospects have never been so bright for new therapies. But some tales are spreading that are fictitious.
doi:10.1038/382283a0
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| | German lessons 283
The German government is to reduce its contribution to European laboratories. Scientists need to be realistic.
doi:10.1038/382283b0
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| | News | |
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| | German budget cuts cast chill wind over outlook for international labs 285
David Dickson, Carl Levitin & Quirin Schiermeier
doi:10.1038/382285a0
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| | Rival Parkinson's bills focus US debate on fetal tissue 286
Meredith Wadman
doi:10.1038/382286a0
PDF (283K)
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| | New chairman sees 'outward-looking' role for science board 286
Colin Macilwain
doi:10.1038/382286b0
PDF (283K)
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| | United States backs climate panel findings 287
Ehsan Masood
doi:10.1038/382287a0
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| | Lobbyists 'belittle climate change science' 287
EHSAN MASOOD
doi:10.1038/382287b0
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| | Funding forces fusion project out of Europe 288
Alison Abbott
doi:10.1038/382288a0
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| | Russian contribution for CERN collider 288
doi:10.1038/382288b0
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| | Budget for US physics 288
doi:10.1038/382288c0
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| | Bollworms chew hole in gene-engineered cotton 289
Colin Macilwain
doi:10.1038/382289a0
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| | Rights issue take-up for British Biotech 'disappointing' 289
Ginny Page
doi:10.1038/382289b0
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| | Brazilian researchers took first bite at 'new muscle' 290
Ricardo Bonalume Neto
doi:10.1038/382290a0
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| | Cash and contacts are keys in the East 290
Alison Abbott
doi:10.1038/382290b0
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| | Outbreak of E. coli infection in Japan renews concerns 290
David Swinbanks
doi:10.1038/382290c0
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| | MPs back increase to fund hadron collider 291
David Dickson
doi:10.1038/382291a0
PDF (258K)
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| | Asbestos removal spells upheaval for Paris scientists 291
Ronnie Amelan
doi:10.1038/382291b0
PDF (258K)
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| | News in Brief | |
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| | News in brief 292
doi:10.1038/382292a0
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| | Correspondence | |
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| | The best athletes are better 294
Nicola Maffulli
doi:10.1038/382294a0
References | PDF (273K)
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| | Greek needs 294
Tassos Economou
doi:10.1038/382294b0
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| | News and Views |  |
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| | Under arrest at atomic resolution 295
Cell proliferation in many tissues is regulated by p27 protein, which binds and inhibits cyclin-dependent kinases. A crystal structure reveals the remarkable mechanisms by which p27 paralyses these enzymes, arresting the cell cycle.
David O. Morgan
doi:10.1038/382295a0
References | PDF (878K)
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| | The shards of broken symmetry 296
Wojciech H. Zurek
doi:10.1038/382296a0
References | PDF (1,363K)
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| | To derive the density of defects: 297
WOJCIECH H. ZUREK
doi:10.1038/382297a0
PDF (652K)
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| | Endless forms, several powers 298
Chung-I Wu & Norman A. Johnson
doi:10.1038/382298a0
References | PDF (559K)
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| | Riding tandems with nature 299
Helmut Ringsdorf
doi:10.1038/382299a0
References | PDF (808K)
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| | The Earth opens up 300
Henry Gee
doi:10.1038/382300a0
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| | Simple worms, complex genes 301
Scott W. Emmons
doi:10.1038/382301a0
References | PDF (1,078K)
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| | Travels on rugged landscapes 302
Mark Buchanan
doi:10.1038/382302a0
References | PDF (862K)
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| | Links in childhood leukaemia 303
Sarah C. Darby & Eve Roman
doi:10.1038/382303a0
References | PDF (628K)
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| | Ultra-infrared 304
David Jones
doi:10.1038/382304a0
PDF (368K)
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| | Scientific Correspondence | |
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| | Hexagonal patterns in laser light 305
J. F. Scott & R. A. O'Sullivan
doi:10.1038/382305a0
References | PDF (415K)
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| | Organization of the visual cortex 306
F. Wolf, H.-U. Bauer, K. Pawelzik & T. Geisel
doi:10.1038/382306a0
References | PDF (328K)
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| | Organization of the visual cortex 306
Tobias Bonhoeffer & Imke Gödecke
doi:10.1038/382306b0
References | PDF (614K)
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| | Feeding inhibition by neuropeptide Y 307
Françoise J. Smith, L. Arthur Campfield, John A. Moschera, Pascal S. Bailon & Paul Burn
doi:10.1038/382307a0
References | PDF (288K)
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| | Function of 14-3-3 proteins 308
Dong-Yan Jin, Myung Soo Lyu, Christine A. Kozak & Kuan-Teh Jeang
doi:10.1038/382308a0
References | PDF (560K)
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| | Function of 14-3-3 proteins 308
Orly Reiner & C. T. Caskey
doi:10.1038/382308b0
References | PDF (560K)
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| | Book Reviews |  |
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| | Evolving evolvability 309
Stuart Kauffman reviews Climbing Mount Improbable
By
Richard Dawkins
doi:10.1038/382309a0
PDF (665K)
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| | Life cycles 310
Nils Chr. Stenseth reviews Do Lemmings Commit Suicide
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Dennis Chitty
doi:10.1038/382310a0
PDF (529K)
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| | 311
doi:10.1038/382311a0
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| | Full circle 311
H. K. Moffatt reviews Turbulence: The Legacy of A. N. Kolmorogov
By
Uriel Frisch
doi:10.1038/382311b0
PDF (554K)
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| | Holes unearthed 312
Stephen Battersby reviews Gravity's Fatal Attraction: Black Holes in the Universe
By
Mitehell Begelmen & Martin Rees
doi:10.1038/382312a0
PDF (285K)
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| | Review Article | |
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| | Synthesis of inorganic materials with complex form 313
Stephen Mann & Geoffrey A. Ozin
doi:10.1038/382313a0
Abstract & References | PDF (1,741K)
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| | Articles |  |
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| | A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A 319
Xiang-Jiao Yang, Vasily V. Ogryzko, Jun-ichi Nishikawa, Bruce H. Howard & Yoshihiro Nakatani
doi:10.1038/382319a0
Abstract & References | PDF (1,737K)
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| | Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A−Cdk2 complex
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Alicia A. Russo, Philip D. Jeffrey, Andrea K. Patten, Joan Massagué & Nikola P. Pavletich
doi:10.1038/382325a0
Abstract & References | PDF (1,953K)
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| | Letters | |
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| | Laboratory simulation of cosmic string formation in the early Universe using superfluid 3He 332
C. Bäuerle, Yu. M. Bunkov, S. N. Fisher, H. Godfrin & G. R. Pickett
doi:10.1038/382332a0
First paragraph & References | PDF (846K)
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| | Vortex formation in neutron-irradiated superfluid 3He as an analogue of cosmological defect formation 334
V. M. H. Ruutu, V. B. Eltsov, A. J. Gill, T. W. B. Kibble, M. Krusius, Yu. G. Makhlin, B. Plaçais, G. E. Volovik & Wen Xu
doi:10.1038/382334a0
First paragraph & References | PDF (798K)
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| | An explanation for the central stress minimum in sand piles 336
J. P. Wittmer, P. Claudin, M. E. Cates & J.-P. Bouchaud
doi:10.1038/382336a0
First paragraph & References | PDF (656K)
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| | Using antibodies to perturb the coordination sphere of a transition metal complex 339
Phalguni Ghosh, Doron Shabat, Sandeep Kumar, Subhash C. Sinha, Flavio Grynszpan, Jian Li, Louis Noodleman & Ehud Keinan
doi:10.1038/382339a0
First paragraph & References | PDF (618K)
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| | Sulphur isotope fractionation in modern microbial mats and the evolution of the sulphur cycle 342
Kirsten S. Habicht & Donald E. Canfield
doi:10.1038/382342a0
First paragraph & References | PDF (477K)
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| | Two-way exchange between the Easter mantle plume and the Easter microplate spreading axis 344
K. M. Haase, C. W. Devey & S. L. Goldstein
doi:10.1038/382344a0
First paragraph & References | PDF (814K)
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| | Eel-like swimming in the earliest ichthyosaurs 347
R. Motani, You H. & C. McGowan
doi:10.1038/382347a0
First paragraph & References | PDF (548K)
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| | A new specimen of Ankarapithecus meteai from the Sinap Formation of central Anatolia 349
Berna Alpagut, Peter Andrews, Mikael Fortelius, John Kappelman, Ilhan Temizsoy, Hürkan Çelebi & William Lindsay
doi:10.1038/382349a0
First paragraph & References | PDF (684K)
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| | Infant leukaemia after in utero exposure to radiation from Chernobyl 352
E. Petridou, D. Trichopoulos, N. Dessypris, V. Flytzani, S. Haidas, M. Kalmanti, D. Koliouskas, H. Kosmidis, F. Piperopoulou & F. Tzortzatou
doi:10.1038/382352a0
First paragraph & References | PDF (454K)
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| | Correct Hox gene expression established independently of position in Caenorhabditis elegans
353
Deborah Cowing & Cynthia Kenyon
doi:10.1038/382353a0
First paragraph & References | PDF (925K)
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| | BMP-4-responsive regulation of dorsal−ventral patterning by the homeobox protein Mix.1 357
Paul E. Mead, Iman H. Brivanlou, Clair M. Kelley & Leonard I. Zon
doi:10.1038/382357a0
First paragraph & References | PDF (1,181K)
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| | The mouse Engrailed-1 gene and ventral limb patterning 360
Cynthia A. Loomis, Esther Harris, Jacques Michaud, Wolfgang Wurst, Mark Hanks & Alexandra L. Joyner
doi:10.1038/382360a0
First paragraph & References | PDF (1,252K)
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| | Influence of dendritic structure on firing pattern in model neocortical neurons 363
Zachary F. Mainen & Terrence J. Sejnowski
doi:10.1038/382363a0
First paragraph & References | PDF (839K)
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| | Critical role for  7 integrins in formation of the gut-associated lymphoid tissue 366
Norbert Wagner, Jürgen Löhler, Eric J. Kunkel, Klaus Ley, Euphemia Leung, Geoff Krissansen, Klaus Rajewsky & Werner Müller
doi:10.1038/382366a0
First paragraph & References | PDF (1,450K)
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| | Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4 370
Futoshi Shibasaki, E. Roydon Price, David Milan & Frank McKeon
doi:10.1038/382370a0
First paragraph & References | PDF (1,144K)
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| | RNA-catalysed RNA polymerization using nucleoside triphosphates 373
Eric H. Ekland & David P. Bartel
doi:10.1038/382373a0
First paragraph & References | PDF (1,088K)
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| | Product Review | |
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| | Labelling techniques 377
This issue covers the reagents and equipment necessary for cellular and molecular imaging and detection, including a luminometer, a phosphor imaging system, reagents to detect intracellular cytokines and alternatives to radiolabelling.
Brendan Horton
doi:10.1038/382377a0
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