Nature Publishing Group, publisher of Nature, and other science journals and reference works
Nature
my account e-alerts subscribe register
   
Tuesday 25 July 2017
Journal Home
Current Issue
AOP
Archive
Download PDF
References
Export citation
Export references
Send to a friend
More articles like this

Letters to Nature
Nature 382, 250 - 252 (18 July 1996); doi:10.1038/382250a0

Role of leptin in the neuroendocrine response to fasting

Rexford S. Ahima*, Daniel Prabakaran*, Christos Mantzoros*, Daqing Qu, Bradford Lowell*, Eleftheria Maratos-Flier & Jeffrey S. Flier*

* Department of Medicine, Division of Endocrinology, Beth Israel Hospital, and Joslin Diabetes Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA

A TOTAL deficiency in or resistance to the protein leptin causes severe obesity1–4. As leptin levels rise with increasing adiposity in rodents5 and man6,7, it is proposed to act as a negative feedback 'adipostatic signal' to brain centres controlling energy homeostasis, limiting obesity in times of nutritional abundance1,3. Starvation is also a threat to homeostasis that triggers adaptive responses8–12, but whether leptin plays a role in the physiology of starvation is unknown. Leptin concentration falls during starvation13 and totally leptin-deficient ob/ob mice have neuroendocrine abnormalities similar to those of starvation14, suggesting that this may be the case. Here we show that preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starvation-induced delay in ovulation in female mice. In contrast, leptin repletion during this period of starvation has little or no effect on body weight, blood glucose or ketones. We propose that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin.

------------------

References

1. Zhang, Y. et al. Nature 372, 425−432 (1994). | Article | PubMed | ISI | ChemPort |
2. Halaas, J. L. et al. Science 269, 543−546 (1995). | PubMed | ISI | ChemPort |
3. Campfield, L. A. et al. Science 269, 546−549 (1995). | PubMed | ISI | ChemPort |
4. Stephens, T. W. et al. Nature 377, 530−532 (1995). | Article | PubMed | ISI | ChemPort |
5. Frederich, R. C. et al. Nature Med. 1, 1311−1314 (1995). | Article | PubMed | ISI | ChemPort |
6. Maffei, M. et al. Nature Med. 1, 1155−1161 (1995). | Article | PubMed | ISI | ChemPort |
7. Considine, R. V. et al. N. Engl. J. Med. 334, 292−295 (1996). | Article | PubMed | ISI | ChemPort |
8. Cahill, J. G. et al. J. clin. Invest. 45, 1751−1769 (1966). | PubMed | ChemPort |
9. Schwartz, M. W., Dallman, M. F. & Woods, S. C. Am. J. Physiol. 269, R949−R957 (1995). | PubMed | ISI | ChemPort |
10. Dallman, M. F. et al. Front. Neuroendocr. 14, 303−347 (1993). | ChemPort |
11. Bronson, F. H. & Marstellar, F. Biol. Reprod. 33, 660−667 (1985). | PubMed | ChemPort |
12. Connors, J. M. et al. Endocrinology 117, 900−906 (1985). | PubMed | ChemPort |
13. Frederich, R. C. et al. J. clin. Invest. 96, 1658−1663 (1995). | PubMed | ISI | ChemPort |
14. Bray, G. A., Fisler, J. & York, D. A. Front. Neuroendocr. 14, 128−181 (1990).
15. Schreihofer, D. A., Amico, J. A. & Cameron, J. L. Endocrinology 132, 1890−1897 (1993). | Article | PubMed | ChemPort |
16. Bates, G. M. Clin. Obstet. Gynec. 28, 632−644 (1985). | PubMed | ChemPort |
17. Tartaglia, L. A. et al. Cell 83, 1263−1271 (1995). | Article | PubMed | ChemPort |
18. Lee, G.-H. et al. Nature 379, 632−635 (1996). | Article | PubMed | ChemPort |
19. White, J. D. & Kershaw, M. Molec. cell. Neurosci. 1, 41−48 (1989).
20. Pierroz, D. Q. et al. Endocrinology 137, 3−12 (1996). | Article | PubMed | ChemPort |
21. Chebab, F. F., Lim, M. E. & Lu, R. Nature Genet. 12, 318−320 (1996). | Article | PubMed | ISI | ChemPort |
22. Erickson, J. C., Clegg, K. E. & Palmiter, R. D. Nature 381, 415−418 (1996). | Article | PubMed | ISI | ChemPort |
23. Cooper, R. L. et al. Endocrinology 114, 391−396 (1984). | PubMed | ChemPort |
24. Qu, D. et al. Nature 380, 243−247 (1996). | Article | PubMed | ISI | ChemPort |



© 1996 Nature Publishing Group
Privacy Policy